3-cyano-3-(2-thienyl)acrylic acid potassium salt

Base Information

• Chemical Name: 3-cyano-3-(2-thienyl)acrylic acid potassium salt
• CAS No.: 912368-67-3
• Molecular Formula: C₈H₄NO₂S*K
• Molecular Weight: 217.29
• Mol file: 912368-67-3.mol

Synonyms:3-cyano-3-(2-thienyl)acrylic acid potassium salt;2-Propenoic acid,3-cyano-3-(2-thienyl)-,potassium salt,(2Z)-;Potassium (Z)-3-cyano-3-(thiophen-2-yl)acrylate

Chemical Property of 3-cyano-3-(2-thienyl)acrylic acid potassium salt

Chemical Property:

• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

Potassium(Z)-3-cyano-3-(thiophen-2-yl)acrylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-cyano-3-(2-thienyl)acrylic acid potassium salt

There total 1 articles about 3-cyano-3-(2-thienyl)acrylic acid potassium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-cyanomethylthiophene (20893-30-5) + Glyoxilic acid (298-12-4) → (2Z)-3-cyano-3-(2-thienyl)acrylic acid potassium salt (912368-67-3)

Guidance literature:

With potassium carbonate; In methanol; for 2h; Inert atmosphere; Reflux;

DOI:10.1021/acs.jmedchem.7b01490

Reference yield:

(2Z)-3-cyano-3-(2-thienyl)acrylic acid potassium salt (912368-67-3) → 2-phenyl-4-[(3S)-piperidin-3-ylamino]thieno[3,2-c]pyridine-7-carboxamide

Guidance literature:

Multi-step reaction with 8 steps

1.1: oxalyl dichloride / dichloromethane / 1 h / 20 °C

2.1: sodium azide / 1,4-dioxane; water / 0 - 20 °C

3.1: tributyl-amine / dichloromethane; diphenylether / 2.17 h / 210 °C / Inert atmosphere

4.1: N-Bromosuccinimide; acetic acid / N,N-dimethyl-formamide / 12 h / 80 °C

4.2: 20 °C / pH 9 - 10

5.1: trichlorophosphate / Reflux

6.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 2 h / 80 °C

7.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere

8.1: water; hydrogenchloride / 24 h

8.2: pH 10 - 11

With hydrogenchloride; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; oxalyl dichloride; tributyl-amine; water; potassium carbonate; caesium carbonate; acetic acid; trichlorophosphate; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; diphenylether; dichloromethane; water; N,N-dimethyl-formamide; 3.1: |Curtius Rearrangement / 7.1: |Suzuki Coupling;

DOI:10.1021/acs.jmedchem.7b01490

Reference yield:

(2Z)-3-cyano-3-(2-thienyl)acrylic acid potassium salt (912368-67-3) → 4-{[(3S)-1-methylpiperidin-3-yl]amino}-2-phenylthieno[3,2-c]pyridine-7-carbonitrile (912369-04-1)

Guidance literature:

Multi-step reaction with 7 steps

1.1: oxalyl dichloride / dichloromethane / 1 h / 20 °C

2.1: sodium azide / 1,4-dioxane; water / 0 - 20 °C

3.1: tributyl-amine / dichloromethane; diphenylether / 2.17 h / 210 °C / Inert atmosphere

4.1: N-Bromosuccinimide; acetic acid / N,N-dimethyl-formamide / 12 h / 80 °C

4.2: 20 °C / pH 9 - 10

5.1: trichlorophosphate / Reflux

6.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 130 °C

7.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; oxalyl dichloride; tributyl-amine; potassium carbonate; caesium carbonate; acetic acid; trichlorophosphate; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; diphenylether; dichloromethane; water; N,N-dimethyl-formamide; 3.1: |Curtius Rearrangement / 7.1: |Suzuki Coupling;

DOI:10.1021/acs.jmedchem.7b01490

upstream raw materials:

2-cyanomethylthiophene

Glyoxilic acid

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