4-(4-Biphenylyl)butanal

Base Information

• Chemical Name: 4-(4-Biphenylyl)butanal
• CAS No.: 122854-65-3
• Molecular Formula: C16H16O
• Molecular Weight: 224.302
• DSSTox Substance ID: DTXSID00695516
• Wikidata: Q82624731
• Mol file: 122854-65-3.mol

Synonyms:4-(4-BIPHENYLYL)BUTANAL;4-(4-phenylphenyl)butanal;122854-65-3;SCHEMBL15453188;DTXSID00695516;4-([1,1'-Biphenyl]-4-yl)butanal

Chemical Property of 4-(4-Biphenylyl)butanal

Chemical Property:

• PSA: 17.07000
• LogP: 3.87520
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 224.120115130
• Heavy Atom Count: 17
• Complexity: 210

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)CCCC=O

Technology Process of 4-(4-Biphenylyl)butanal

There total 10 articles about 4-(4-Biphenylyl)butanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

→ 4-([1,1'-biphenyl]-4-yl)butanal (122854-65-3)

Guidance literature:

With tetrafluoroboric acid diethyl ether; In chloroform; for 12h; Reflux;

With tetrabutyl ammonium fluoride; dihydrogen peroxide; potassium hydrogencarbonate; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

Reference yield: 74.0%

p-vinylbiphenyl (2350-89-2) + ethyl vinyl ether (109-92-2,25104-37-4) → 4-([1,1'-biphenyl]-4-yl)butanal (122854-65-3)

Guidance literature:

With 10-phenyl-9-(2,4,6-trimethylphenyl)acridinium tetrafluoroborate; diphenyldisulfane; In 1,2-dichloro-ethane; chemoselective reaction; Inert atmosphere; Irradiation;

DOI:10.1002/anie.201712384

Reference yield: 68.0%

(R)-(4-([1,1′-biphenyl]-4-yl)-1-(phenylsilyl)butyl)diphenylsilane → 4-([1,1'-biphenyl]-4-yl)butanal (122854-65-3)

Guidance literature:

(R)-(4-([1,1′-biphenyl]-4-yl)-1-(phenylsilyl)butyl)diphenylsilane; With tetrafluoroboric acid diethyl ether complex; In chloroform; for 12h; Reflux;

With tetrabutyl ammonium fluoride; dihydrogen peroxide; potassium hydrogencarbonate; In methanol; at 20 ℃; for 2h;

upstream raw materials:

4-iodo-biphenyl

4-([1,1'-biphenyl]-4-yl)but-3-yn-1-ol

4-(biphenyl-4-yl)butanol

p-vinylbiphenyl

Downstream raw materials:

1-(1-(4-([1,1'-biphenyl]-4-yl)butyl)piperidin-4-yl)-3-ethylindolin-2-one

p-methoxyphenyl (9-(4-(4-biphenyl)butyl)amino-3,5,9-trideoxy-5-glycolamido-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2->6)-β-D-galactopyranoside

Refernces

• 1、 Xu, Yan,Qi, Xiaotian,Zheng, Pengfei,Berti, Carlo C.,Liu, Peng,Dong, Guangbin. "Deacylative transformations of ketones via aromatization-promoted C–C bond activation". . p. 373 - 378. Retrieved 2019/05/22.
• 2、 Wu, Fu-Peng,Li, Da,Peng, Jin-Bao,Wu, Xiao-Feng. "Carbonylative Transformation of Allylarenes with CO Surrogates: Tunable Synthesis of 4-Arylbutanoic Acids, 2-Arylbutanoic Acids, and 4-Arylbutanals". supporting information. p. 5699 - 5703. Retrieved 2019/08/01.