4-Isopropoxypyridine

Base Information

• Chemical Name: 4-Isopropoxypyridine
• CAS No.: 53708-19-3
• Molecular Formula: C8H11NO
• Molecular Weight: 137.17904
• DSSTox Substance ID: DTXSID70403963
• Nikkaji Number: J1.361.201C
• Wikidata: Q82207879
• Mol file: 53708-19-3.mol

Synonyms:4-ISOPROPOXYPYRIDINE;4-propan-2-yloxypyridine;53708-19-3;4-(propan-2-yloxy)pyridine;4-n-isopropoxypyridine;ghl.PD_Mitscher_leg0.276;SCHEMBL8129230;DTXSID70403963;AKOS006282509;EN300-71448;Z1140308716

Chemical Property of 4-Isopropoxypyridine

Chemical Property:

• PSA: 22.12000
• LogP: 1.86880
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 137.084063974
• Heavy Atom Count: 10
• Complexity: 87.3

Purity/Quality:

98%Min ^*data from raw suppliers

4-(Propan-2-yloxy)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)OC1=CC=NC=C1
• Uses: 4-(propan-2-yloxy)pyridine (cas# 53708-19-3) is used in the mass spectral study of isomeric dependence of formation of ion/neutral complexes in dissociation reactions of ionized propoxypyridines.

Technology Process of 4-Isopropoxypyridine

There total 3 articles about 4-Isopropoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-isopropoxypyridine-N-oxide (26883-28-3) → 4-isopropoxypyridine (53708-19-3)

Guidance literature:

With sulfuric acid; zinc; at 80 ℃; for 0.5h; Yield given;

Reference yield:

4-nitraminopyridine N-oxide (1124-33-0) → 4-isopropoxypyridine (53708-19-3)

Guidance literature:

Multi-step reaction with 2 steps

1: propan-2-ol / 1 h / Heating

2: 1 M H₂SO₄, Zn / 0.5 h / 80 °C

With sulfuric acid; zinc; In isopropyl alcohol;

Reference yield:

→ 4-isopropoxypyridine (53708-19-3)

Guidance literature:

γ-Phenoxypyridin, Na-Isopropanolat;

upstream raw materials:

4-isopropoxypyridine-N-oxide

4-nitraminopyridine N-oxide

Downstream raw materials:

benzyl 4-oxo-3,4-dihydropyridine-1(2H)-carboxylate

6-(4,4-Dibromo-but-3-enyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

6-Pent-3-ynyl-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

6-But-3-ynyl-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester