Benzyl-[1-(4-cyclohexylphenyl)ethyl]amine

Base Information

• Chemical Name: Benzyl-[1-(4-cyclohexylphenyl)ethyl]amine
• CAS No.: 74068-21-6
• Molecular Formula: C21H27N
• Molecular Weight: 293.45
• European Community (EC) Number: 673-489-7
• DSSTox Substance ID: DTXSID40373447
• Mol file: 74068-21-6.mol

Synonyms:Benzyl-[1-(4-cyclohexylphenyl)ethyl]amine;N-benzyl-1-(4-cyclohexylphenyl)ethanamine;74068-21-6;AC1MBTZL;DTXSID40373447;benzyl [1-(4-cyclohexylphenyl)ethyl]amine

Chemical Property of Benzyl-[1-(4-cyclohexylphenyl)ethyl]amine

Chemical Property:

• PSA: 12.03000
• LogP: 5.97600
• XLogP3: 5.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 293.214349865
• Heavy Atom Count: 22
• Complexity: 293

Purity/Quality:

98%min ^*data from raw suppliers

BENZYL-[1-(4-CYCLOHEXYLPHENYL)ETHYL]AMINE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C1=CC=C(C=C1)C2CCCCC2)NCC3=CC=CC=C3

Technology Process of Benzyl-[1-(4-cyclohexylphenyl)ethyl]amine

There total 4 articles about Benzyl-[1-(4-cyclohexylphenyl)ethyl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

[1-(4-Cyclohexyl-phenyl)-ethyl]-[1-phenyl-meth-(E)-ylidene]-amine (74068-20-5) → α-metil-4-cicloesil-N-benzilbenzilammina (74068-21-6)

Guidance literature:

With sodium tetrahydroborate; In methanol; water; for 2h; Heating;

Reference yield:

4-cyclohexylacetophenone (18594-05-3) → α-metil-4-cicloesil-N-benzilbenzilammina (74068-21-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 85 percent / hydroxylamine hydrochloride, NaOH / ethanol; H₂O / 5 h / Heating

2: 76 percent / hydrogen / 10percent Pd/C / ethanol / 3040 Torr / Ambient temperature

3: 84 percent / methanol / 7 h / Heating

4: 83 percent / NaBH₄ / methanol; H₂O / 2 h / Heating

With sodium hydroxide; sodium tetrahydroborate; hydroxylamine hydrochloride; hydrogen; palladium on activated charcoal; In methanol; ethanol; water;

Reference yield:

ossima del 4-cicloesilacetofenone (74067-99-5) → α-metil-4-cicloesil-N-benzilbenzilammina (74068-21-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / hydrogen / 10percent Pd/C / ethanol / 3040 Torr / Ambient temperature

2: 84 percent / methanol / 7 h / Heating

3: 83 percent / NaBH₄ / methanol; H₂O / 2 h / Heating

With sodium tetrahydroborate; hydrogen; palladium on activated charcoal; In methanol; ethanol; water;

upstream raw materials:

[1-(4-Cyclohexyl-phenyl)-ethyl]-[1-phenyl-meth-(E)-ylidene]-amine

α-metil-4-cicloesilbenzilammina

4-cyclohexylacetophenone

ossima del 4-cicloesilacetofenone

Downstream raw materials:

5-(2-{Benzyl-[1-(4-cyclohexyl-phenyl)-ethyl]-amino}-acetyl)-2-benzyloxy-benzoic acid methyl ester