valylleucyl-N-{4-[bis(2-chloroethyl)amino]phenyl}lysinamide trifluoroacetate (1:1)

Base Information

Chemical Name:valylleucyl-N-{4-[bis(2-chloroethyl)amino]phenyl}lysinamide trifluoroacetate (1:1)
CAS No.:84559-75-1
Molecular Formula:C29H47Cl2F3N6O5
Molecular Weight:801.655
Hs Code.:

Synonyms:

Suppliers and Price of valylleucyl-N-{4-[bis(2-chloroethyl)amino]phenyl}lysinamide trifluoroacetate (1:1)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 3 raw suppliers

Chemical Property of valylleucyl-N-{4-[bis(2-chloroethyl)amino]phenyl}lysinamide trifluoroacetate (1:1)

Chemical Property:

Vapor Pressure:3.84E-27mmHg at 25°C
Boiling Point:822.1°Cat760mmHg
Flash Point:451°C
Density:g/cm³

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of valylleucyl-N-{4-[bis(2-chloroethyl)amino]phenyl}lysinamide trifluoroacetate (1:1)

There total 10 articles about valylleucyl-N-{4-[bis(2-chloroethyl)amino]phenyl}lysinamide trifluoroacetate (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 84559-73-9
N-α-(tert-buthoxycarbonyl)-D-valylleucyl-N^ε-(tert-buthoxycarbonyl)lysyl>-N',N'-bis(2-chloroethyl)-p-phenylenediamine

: 76-05-1
trifluoroacetic acid

: 84559-75-1
N-(D-valylleucyllysyl)-N',N'-bis(2-chloroethyl)-p-phenylenediamine bis(trifluoroacetate)

Guidance literature:: In dichloromethane; for 0.5h; Ambient temperature;
DOI:10.1021/jm00359a003

Reference yield:

: 2067-58-5
4-amino-N,N-bis(2-chloroethyl)aniline

: 84559-75-1
N-(D-valylleucyllysyl)-N',N'-bis(2-chloroethyl)-p-phenylenediamine bis(trifluoroacetate)

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) N-methylmorpholine, isobutyl chloroformate, 2.) N-methylmorpholine / 1.) THF, -15 - -10 deg, 15 min., 2.) THF, DMF, a) -15 - -10 deg, 2h, b) RT, overnight

2: 94 percent / CH₂Cl₂ / 0.5 h / Ambient temperature

With 4-methyl-morpholine; isobutyl chloroformate; In dichloromethane;
DOI:10.1021/jm00359a003

Reference yield:

: 22838-58-0
Boc-D-Val-OH

: 84559-75-1
N-(D-valylleucyllysyl)-N',N'-bis(2-chloroethyl)-p-phenylenediamine bis(trifluoroacetate)

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / triethylamine, dicyclohexylcarbodiimide (DCC), 1-hydroxybenzotriazole (HOBT) H₂O / dimethylformamide; CH₂Cl₂ / 4 h / 0 °C

2: 98 percent / H₂ / 5percent PdC / methanol

3: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -15 - -10 deg, 15 min., 2.) THF, DMF, a) -15 - -10 deg, 2h, b) RT, overnight

4: 86 percent / NaOH / dimethylformamide; acetone / 1 h / Ambient temperature

5: 1.) N-methylmorpholine, isobutyl chloroformate, 2.) N-methylmorpholine / 1.) THF, -15 - -10 deg, 15 min., 2.) THF, DMF, a) -15 - -10 deg, 2h, b) RT, overnight

6: 94 percent / CH₂Cl₂ / 0.5 h / Ambient temperature

With 4-methyl-morpholine; sodium hydroxide; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; isobutyl chloroformate; dipyridinium dichromate; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00359a003