tert-butyl 5-oxa-2,8-diazaspiro[3.5]nonane-8-carboxylate

Base Information

• Chemical Name: tert-butyl 5-oxa-2,8-diazaspiro[3.5]nonane-8-carboxylate
• CAS No.: 1251005-61-4
• Molecular Formula: C11H20N2O3
• Molecular Weight: 228.291
• Hs Code.: 2934999090
• Mol file: 1251005-61-4.mol

Synonyms:tert-butyl 5-oxa-2,8-diazaspiro[3.5]nonane-8-carboxylate;8-Boc-5-oxa-2,8-diaza-spiro[3.5]nonane

Chemical Property of tert-butyl 5-oxa-2,8-diazaspiro[3.5]nonane-8-carboxylate

Chemical Property:

• PSA: 50.80000
• LogP: 0.86240
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butyl 5-oxa-2,8-diazaspiro[3.5]nonane-8-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 5-oxa-2,8-diazaspiro[3.5]nonane-8-carboxylate

There total 6 articles about tert-butyl 5-oxa-2,8-diazaspiro[3.5]nonane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

tert-butyl 2-(diphenylmethyl)-5-oxa-2,8-diazaspiro[3.5]nonane-8-carboxylate (1263268-96-7) → tert-butyl 5-oxa-2,8-diazaspiro[3.5]nonane-8-carboxylate (1251005-61-4)

Guidance literature:

With palladium 10% on activated carbon; ammonium formate; In ethanol; for 0.5h; Reflux;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 5-oxa-2,8-diazaspiro[3.5]nonane-8-carboxylate (1251005-61-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 18 h / 20 °C

2: ammonium formate / 10% palladium on activated charcoal / ethanol / 0.5 h / Reflux

With ammonium formate; triethylamine; 10% palladium on activated charcoal; In ethanol; dichloromethane;

Reference yield:

2-benzhydryl-5-oxa-2,8-diazaspiro[3.5]nonane dihydrochloride → tert-butyl 5-oxa-2,8-diazaspiro[3.5]nonane-8-carboxylate (1251005-61-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 18 h / 20 °C

2: ammonium formate / 10% palladium on activated charcoal / ethanol / 0.5 h / Reflux

With ammonium formate; triethylamine; 10% palladium on activated charcoal; In ethanol; dichloromethane;

upstream raw materials:

di-tert-butyl dicarbonate

tert-butyl 2-(diphenylmethyl)-5-oxa-2,8-diazaspiro[3.5]nonane-8-carboxylate

2-(diphenylmethyl)-5-oxa-2,8-diazaspiro[3.5]nonan-7-one

2-(diphenylmethyl)-5-oxa-2,8-diazaspiro[3.5]nonane

Downstream raw materials:

tert-Butyl 2-(3-(2-hydroxyethyl)phenethyl)-5-oxa-2,8-diazaspiro[3.5]nonane-8-carboxylate

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