Carbamic acid, (5-((3-amino-2,3-dihydro-2-hydroxy-1H-inden-1-yl)amino)-2-hydroxy-5-oxo-1,4-bis(phenylmethyl)pentyl)-, 1,1-dimethylethyl ester, (1S-(1a(1R,2R,4S*),2alpha,3alpha))-

Base Information

Chemical Name:Carbamic acid, (5-((3-amino-2,3-dihydro-2-hydroxy-1H-inden-1-yl)amino)-2-hydroxy-5-oxo-1,4-bis(phenylmethyl)pentyl)-, 1,1-dimethylethyl ester, (1S-(1a(1R*,2R*,4S*),2alpha,3alpha))-
CAS No.:132565-19-6
Molecular Formula:C33H41N3O5
Molecular Weight:559.6957
Hs Code.:
DSSTox Substance ID:DTXSID20157641
Nikkaji Number:J384.465J
Wikidata:Q83025800

Carbamic acid, (5-((3-amino-2,3-dihydro-2-hydroxy-1H-inden-1-yl)amino)-2-hydroxy-5-oxo-1,4-bis(phenylmethyl)pentyl)-, 1,1-dimethylethyl ester, (1S-(1a(1R*,2R*,4S*),2alpha,3alpha))-

Synonyms:132565-19-6;Carbamic acid, (5-((3-amino-2,3-dihydro-2-hydroxy-1H-inden-1-yl)amino)-2-hydroxy-5-oxo-1,4-bis(phenylmethyl)pentyl)-, 1,1-dimethylethyl ester, (1S-(1a(1R*,2R*,4S*),2alpha,3alpha))-;N-t-Butyloxycarbonyl-5-amino-1,6-diphenyl-4-hydroxy-2-(3-amino-2-hydroxyindanacetylamino);BDBM843;DTXSID20157641;(2R,4S,5S)-2-Benzyl-5-(tert-butyloxycarbonylamino)-N-[[(1S)-3alpha-amino-2,3-dihydro-2alpha-hydroxy-1H-inden]-1alpha-yl]-4-hydroxy-6-phenylhexanamide;Carbamic acid, [5-[(3-amino-2,3-dihydro-2-hydroxy-1H-inden-1-yl)amino]-2-hydroxy-5-oxo-1,4-bis(phenylmethyl)pentyl]-, 1,1-dimethylethyl ester, [1S-[1a(1R*,2R*,4S*),2a,3a]]-;tert-butyl N-[(1S,2S,4R)-5-[[(1S,2R,3R)-3-amino-2-hydroxy-indan-1-yl]amino]-1,4-dibenzyl-2-hydroxy-5-oxo-pentyl]carbamate;tert-butyl N-[(2S,3S,5R)-5-{[(1S,2R,3R)-3-amino-2-hydroxy-2,3-dihydro-1H-inden-1-yl]carbamoyl}-5-benzyl-3-hydroxy-1-phenylpentan-2-yl]carbamate

Suppliers and Price of Carbamic acid, (5-((3-amino-2,3-dihydro-2-hydroxy-1H-inden-1-yl)amino)-2-hydroxy-5-oxo-1,4-bis(phenylmethyl)pentyl)-, 1,1-dimethylethyl ester, (1S-(1a(1R*,2R*,4S*),2alpha,3alpha))-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Carbamic acid, (5-((3-amino-2,3-dihydro-2-hydroxy-1H-inden-1-yl)amino)-2-hydroxy-5-oxo-1,4-bis(phenylmethyl)pentyl)-, 1,1-dimethylethyl ester, (1S-(1a(1R*,2R*,4S*),2alpha,3alpha))-

Chemical Property:

Vapor Pressure:3.57E-28mmHg at 25°C
Boiling Point:816.2°Cat760mmHg
Flash Point:447.4°C
Density:1.24g/cm³
XLogP3:3.5
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:12
Exact Mass:559.30462142
Heavy Atom Count:41
Complexity:835

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC(CC1=CC=CC=C1)C(CC(CC2=CC=CC=C2)C(=O)NC3C(C(C4=CC=CC=C34)N)O)O
Isomeric SMILES:CC(C)(C)OC(=O)N[C@@H](CC1=CC=CC=C1)[C@H](C[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H]3[C@@H]([C@@H](C4=CC=CC=C34)N)O)O

Technology Process of Carbamic acid, (5-((3-amino-2,3-dihydro-2-hydroxy-1H-inden-1-yl)amino)-2-hydroxy-5-oxo-1,4-bis(phenylmethyl)pentyl)-, 1,1-dimethylethyl ester, (1S-(1a(1R*,2R*,4S*),2alpha,3alpha))-

There total 7 articles about Carbamic acid, (5-((3-amino-2,3-dihydro-2-hydroxy-1H-inden-1-yl)amino)-2-hydroxy-5-oxo-1,4-bis(phenylmethyl)pentyl)-, 1,1-dimethylethyl ester, (1S-(1a(1R*,2R*,4S*),2alpha,3alpha))- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132565-26-5
((1R,2R,3S)-3-Azido-2-hydroxy-indan-1-yl)-carbamic acid tert-butyl ester

: 132565-19-6
[(1S,2S,4R)-4-((1S,2R,3R)-3-Amino-2-hydroxy-indan-1-ylcarbamoyl)-1-benzyl-2-hydroxy-5-phenyl-pentyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) TFA / 1.) CH₂Cl₂, 2.) DMF

2: Ph₃P / tetrahydrofuran

3: H₂ / Pd/C

4: EDC, HOBT, TEA / dimethylformamide

5: tetrabutylammonium fluoride / tetrahydrofuran

With TEA; tetrabutyl ammonium fluoride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triphenylphosphine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00107a051

Reference yield:

: 132565-28-7
((1R,2S,3S)-3-Amino-2-hydroxy-indan-1-yl)-carbamic acid benzyl ester

: 132565-19-6
[(1S,2S,4R)-4-((1S,2R,3R)-3-Amino-2-hydroxy-indan-1-ylcarbamoyl)-1-benzyl-2-hydroxy-5-phenyl-pentyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C

2: EDC, HOBT, TEA / dimethylformamide

3: tetrabutylammonium fluoride / tetrahydrofuran

With TEA; tetrabutyl ammonium fluoride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00107a051

Reference yield:

: 132565-27-6
((1R,2R,3S)-3-Azido-2-hydroxy-indan-1-yl)-carbamic acid benzyl ester

: 132565-19-6
[(1S,2S,4R)-4-((1S,2R,3R)-3-Amino-2-hydroxy-indan-1-ylcarbamoyl)-1-benzyl-2-hydroxy-5-phenyl-pentyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Ph₃P / tetrahydrofuran

2: H₂ / Pd/C

3: EDC, HOBT, TEA / dimethylformamide

4: tetrabutylammonium fluoride / tetrahydrofuran

With TEA; tetrabutyl ammonium fluoride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00107a051