tert-Butyl (5-hydroxypiperidin-3-yl)carbamate

Base Information

Chemical Name:tert-Butyl (5-hydroxypiperidin-3-yl)carbamate
CAS No.:1502766-14-4
Molecular Formula:C10H20N2O3
Molecular Weight:216.28
Hs Code.:
Mol file:1502766-14-4.mol

Synonyms:tert-Butyl (5-hydroxypiperidin-3-yl)carbamate;tert-butyl N-(5-hydroxypiperidin-3-yl)carbamate

Suppliers and Price of tert-Butyl (5-hydroxypiperidin-3-yl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
tert-butylN-(5-hydroxypiperidin-3-yl)carbamate
100mg
$ 155.00

Crysdot
tert-Butyl(5-hydroxypiperidin-3-yl)carbamate 95+%
1g
$ 470.00

Chemenu
tert-Butyl(5-hydroxypiperidin-3-yl)carbamate 95%
1g
$ 491.00

American Custom Chemicals Corporation
TERT-BUTYL N-(5-HYDROXYPIPERIDIN-3-YL)CARBAMATE 95.00%
5MG
$ 450.61

Alichem
tert-Butyl(5-hydroxypiperidin-3-yl)carbamate
1g
$ 540.75

AK Scientific
Tert-butylN-(5-hydroxypiperidin-3-yl)carbamate
5g
$ 1403.00

Total 8 raw suppliers

Chemical Property of tert-Butyl (5-hydroxypiperidin-3-yl)carbamate

Chemical Property:

Boiling Point:363.4±42.0 °C(Predicted)
PKA:12.06±0.40(Predicted)
PSA：70.59000
Density:1.11±0.1 g/cm3(Predicted)
LogP:0.95360
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

tert-butylN-(5-hydroxypiperidin-3-yl)carbamate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-Butyl (5-hydroxypiperidin-3-yl)carbamate

There total 18 articles about tert-Butyl (5-hydroxypiperidin-3-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1611481-19-6
tert-butyl ((3S,5R)-1-benzyl-5-hydroxypiperidin-3-yl)carbamate

: 849161-66-6,1502766-14-4
tert-butyl N-[(3S,5R)-5-hydroxy-3-piperidyl]carbamate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1002/chem.201302423

Reference yield: 80.0%

: 1611481-20-9
tert-butyl ((3S,5R)-1-benzyl-5-hydroxypiperidin-3-yl)carbamate

: 1611481-21-0,1502766-14-4
tert-butyl (3R,5S)-5-hydroxypiperidin-3-ylcarbamate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1002/chem.201302423

Reference yield:

: 51-35-4,30724-02-8
4R-4-hydroxyproline

: 849161-66-6,1502766-14-4
tert-butyl N-[(3S,5R)-5-hydroxy-3-piperidyl]carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: thionyl chloride / 77 h / 0 - 20 °C / Inert atmosphere; Reflux

2.1: triethylamine / dichloromethane / 5.25 h / 0 °C / Inert atmosphere; Reflux

3.1: triethylamine / dichloromethane / 14 h / 0 °C / Inert atmosphere

4.1: tetrabutylammoniun azide / acetonitrile / 1 h / 70 °C / Inert atmosphere

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 - 20 °C / Inert atmosphere

6.1: 1,4-dioxane / 20 h / 20 °C / Inert atmosphere

7.1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 8 h / 0 - 100 °C / Inert atmosphere; Microwave irradiation

7.2: 1 h / 20 °C / Inert atmosphere; Microwave irradiation

8.1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; thionyl chloride; palladium 10% on activated carbon; hydrogen; tetrabutylammoniun azide; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; acetonitrile;
DOI:10.1002/chem.201302423