methyl 3-(morpholin-4-ylsulfonyl)thiophene-2-carboxylate

Base Information

• Chemical Name: methyl 3-(morpholin-4-ylsulfonyl)thiophene-2-carboxylate
• CAS No.: 895261-67-3
• Molecular Formula: C₁₀H₁₃NO₅S₂
• Molecular Weight: 291.349
• Hs Code.: 2935009090
• Mol file: 895261-67-3.mol

Synonyms:methyl 3-(morpholin-4-ylsulfonyl)thiophene-2-carboxylate

Chemical Property of methyl 3-(morpholin-4-ylsulfonyl)thiophene-2-carboxylate

Chemical Property:

• PSA: 109.53000
• LogP: 1.57430

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 3-(morpholin-4-ylsulfonyl)thiophene-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 3-(morpholin-4-ylsulfonyl)thiophene-2-carboxylate

There total 2 articles about methyl 3-(morpholin-4-ylsulfonyl)thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

morpholine (110-91-8,99108-56-2) + 2-(methoxycarbonyl)thiophene-3-diazonium tetrafluoroborate → methyl 3-(morpholinosulfonyl)thiophene-2-carboxylate (895261-67-3)

Guidance literature:

2-(methoxycarbonyl)thiophene-3-diazonium tetrafluoroborate; With 1,4-diazabicyclo[2.2.2]octane-triethylenediamine-bis(sulfur dioxide); benzotriazol-1-ol; In 1,2-dichloro-ethane; at 60 ℃; for 1h; Inert atmosphere;

morpholine; With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/adsc.201700501

Reference yield: 31.0%

4-chloromorpholine (23328-69-0) + 2-(methoxycarbonyl)thiophene-3-diazonium tetrafluoroborate → methyl 3-(morpholinosulfonyl)thiophene-2-carboxylate (895261-67-3)

Guidance literature:

With 1,4-diazabicyclo [2.2.2] octane-1,4-diium-1,4-disulfinate; copper(II) bis(trifluoromethanesulfonate); isopropyl alcohol; In 1,2-dichloro-ethane; at 80 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b00093

upstream raw materials:

morpholine

4-chloromorpholine

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