Methyl 4,5,6,7-tetrahydro-[1,2,3]triazolo[1,5-a]pyrazine-3-carboxylate

Base Information

• Chemical Name: Methyl 4,5,6,7-tetrahydro-[1,2,3]triazolo[1,5-a]pyrazine-3-carboxylate
• CAS No.: 1211538-23-6
• Molecular Formula: C7H10N4O2
• Molecular Weight: 182.182
• Hs Code.: 2933990090
• Mol file: 1211538-23-6.mol

Synonyms:Methyl 4,5,6,7-tetrahydro-[1,2,3]triazolo[1,5-a]pyrazine-3-carboxylate

Chemical Property of Methyl 4,5,6,7-tetrahydro-[1,2,3]triazolo[1,5-a]pyrazine-3-carboxylate

Chemical Property:

• PSA: 69.04000
• LogP: -0.50330

Purity/Quality:

98% ^*data from raw suppliers

Methyl4,5,6,7-tetrahydro-[1,2,3]triazolo[1,5-a]pyrazine-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 4,5,6,7-tetrahydro-[1,2,3]triazolo[1,5-a]pyrazine-3-carboxylate

There total 5 articles about Methyl 4,5,6,7-tetrahydro-[1,2,3]triazolo[1,5-a]pyrazine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(5-boc-4,5,6,7-tetrahydro-[1,2,3]triazolo[1,5-a]pyrazin-3-yl)methyl acetate (1293995-80-8) → C7H10N4O2 (1211538-23-6)

Guidance literature:

Multi-step reaction with 4 steps

1: water; lithium hydroxide / methanol / 2 h / 20 °C

2: iodine; potassium carbonate / 3 h / 50 °C / Inert atmosphere

3: Reflux

4: trifluoroacetic acid / dichloromethane

With water; iodine; potassium carbonate; trifluoroacetic acid; lithium hydroxide; In methanol; dichloromethane;

DOI:10.1016/j.bmcl.2011.01.086

Reference yield:

C13H20N4O4 (1293995-77-3) → C7H10N4O2 (1211538-23-6)

Guidance literature:

Multi-step reaction with 5 steps

1: dimethyl sulfoxide / 150 °C

2: water; lithium hydroxide / methanol / 2 h / 20 °C

3: iodine; potassium carbonate / 3 h / 50 °C / Inert atmosphere

4: Reflux

5: trifluoroacetic acid / dichloromethane

With water; iodine; potassium carbonate; trifluoroacetic acid; lithium hydroxide; In methanol; dichloromethane; dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2011.01.086

Reference yield:

tert-butyl 6,7-dihydro-3-(hydroxymethyl)-[1,2,3]triazolo[1,5-a]pyrazine-5(4H)-carboxylate (1251002-72-8) → C7H10N4O2 (1211538-23-6)

Guidance literature:

Multi-step reaction with 3 steps

1: iodine; potassium carbonate / 3 h / 50 °C / Inert atmosphere

2: Reflux

3: trifluoroacetic acid / dichloromethane

With iodine; potassium carbonate; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2011.01.086

upstream raw materials:

(5-boc-4,5,6,7-tetrahydro-[1,2,3]triazolo[1,5-a]pyrazin-3-yl)methyl acetate

C₁₃H₂₀N₄O₄

tert-butyl 6,7-dihydro-3-(hydroxymethyl)-[1,2,3]triazolo[1,5-a]pyrazine-5(4H)-carboxylate

5-tert-butyl 3-(2,2,2-trifluoroethyl) 6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazine-3,5(4H)-dicarboxylate

Downstream raw materials:

C₁₇H₁₈F₃N₅O₃

(R)-3-amino-4-(2,4,5-trifluorophenyl)-1-(3-(methoxycarbonyl)-6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)butan-1-one hydrochloride

C₂₂H₂₆F₃N₅O₅

Refernces