CHEMBRDG-BB 4001931

Base Information

• Chemical Name: CHEMBRDG-BB 4001931
• CAS No.: 22727-43-1
• Molecular Formula: C₈H₉N₃O
• Molecular Weight: 163.179
• Mol file: 22727-43-1.mol

Synonyms:CHEMBRDG-BB 4001931;4,6-DIMETHYLFURO[2,3-D]PYRIMIDIN-2-AMINE;4,6-dimethylfuro[2,3-d]pyrimidin-2-amine(SALTDATA: FREE)

Chemical Property of CHEMBRDG-BB 4001931

Chemical Property:

• Vapor Pressure: 3.49E-05mmHg at 25°C
• Melting Point: 246-248 °C(Solv: hexane (110-54-3))
• Boiling Point: 353.8°C at 760 mmHg
• PKA: 3.84±0.40(Predicted)
• Flash Point: 167.8°C
• PSA: 64.94000
• Density: 1.278g/cm³
• LogP: 2.00300

Purity/Quality:

98% ^*data from raw suppliers

4,6-dimethylfuro[2,3-d]pyrimidin-2-amine ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CHEMBRDG-BB 4001931

There total 9 articles about CHEMBRDG-BB 4001931 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,6-dimethyl-1H-furo[2,3-d]pyrimidine-2-thione (22727-33-9) → 4,6-dimethylfuro[2,3-d]pyrimidin-2-amine (22727-43-1)

Guidance literature:

Multi-step reaction with 3 steps

1: KOH / methanol

2: H₂O₂ / formic acid

3: aq. NH₃ / 120 °C

With potassium hydroxide; ammonium hydroxide; dihydrogen peroxide; In methanol; formic acid;

Reference yield:

6-methyl-5-(2-oxo-propyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (22727-23-7) → 4,6-dimethylfuro[2,3-d]pyrimidin-2-amine (22727-43-1)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂SO₄

2: KOH / methanol

3: H₂O₂ / formic acid

4: aq. NH₃ / 120 °C

With potassium hydroxide; ammonium hydroxide; sulfuric acid; dihydrogen peroxide; In methanol; formic acid;

Reference yield:

2-methanesulfonyl-4,6-dimethyl-furo[2,3-d]pyrimidine (22727-38-4) → 4,6-dimethylfuro[2,3-d]pyrimidin-2-amine (22727-43-1)

Guidance literature:

With ammonium hydroxide; at 120 ℃;

upstream raw materials:

2-methanesulfonyl-4,6-dimethyl-furo[2,3-d]pyrimidine

2-ethanesulfonyl-4,6-dimethyl-furo[2,3-d]pyrimidine

4,6-dimethyl-1H-furo[2,3-d]pyrimidine-2-thione

4,6-dimethyl-2-methylsulfanyl-furo[2,3-d]pyrimidine

Downstream raw materials:

2-chloro-4,6-dimethylfuro[2,3-d]pyrimidine

Refernces