3-(2'-DEOXY-BETA-D-2-RIBOFURANOSYL)PYRIDO[2,3-D]PYRIMIDINE-2,7(8H)-DIONE

Base Information

• Chemical Name: 3-(2'-DEOXY-BETA-D-2-RIBOFURANOSYL)PYRIDO[2,3-D]PYRIMIDINE-2,7(8H)-DIONE
• CAS No.: 99517-98-3
• Molecular Formula: C₁₂H₁₃N₃O₅
• Molecular Weight: 279.252
• Hs Code.: 2931900090
• Mol file: 99517-98-3.mol

Synonyms:3-(2'-DEOXY-BETA-D-2-RIBOFURANOSYL)PYRIDO[2,3-D]PYRIMIDINE-2,7(8H)-DIONE;DF;DF NUCLEOSIDE;ANTI-CFD (N-TERM) antibody produced in rabbit;CFD

Chemical Property of 3-(2'-DEOXY-BETA-D-2-RIBOFURANOSYL)PYRIDO[2,3-D]PYRIMIDINE-2,7(8H)-DIONE

Chemical Property:

• PSA: 117.44000
• LogP: -1.27450
• Storage Temp.: -196°C

Purity/Quality:

97% ^*data from raw suppliers

CFD ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-(2’-Deoxy-β-D-2-ribofuranosyl)pyrido[2,3-d]pyrimidine-2,7(8H)-dione is incorporated into triple helix-forming oligonucleotides (TFOs) thus enhancing the potential to specifically modulate expression of gene in a sequence dependant manner.

Technology Process of 3-(2'-DEOXY-BETA-D-2-RIBOFURANOSYL)PYRIDO[2,3-D]PYRIMIDINE-2,7(8H)-DIONE

There total 1 articles about 3-(2'-DEOXY-BETA-D-2-RIBOFURANOSYL)PYRIDO[2,3-D]PYRIMIDINE-2,7(8H)-DIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(tert-butoxycarbonylmethyl)triphenylphosphonium bromide (59159-39-6) + 5-formyl-2′-deoxycytidine (137017-45-9) → 3-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrido[2,3-d]pyrimidine-2,7(3H,8H)-dione (99517-98-3)

Guidance literature:

With sodium hydrogencarbonate; at 60 ℃; for 2h;

DOI:10.1039/d0cc04950f

upstream raw materials:

(tert-butoxycarbonylmethyl)triphenylphosphonium bromide

5-formyl-2′-deoxycytidine