(S)-2-(AdaMantan-1-yl)-2-aMinoacetic acid hydrochloride

Base Information

• Chemical Name: (S)-2-(AdaMantan-1-yl)-2-aMinoacetic acid hydrochloride
• CAS No.: 102502-64-7
• Molecular Formula: C12H20ClNO2
• Molecular Weight: 245.749
• Mol file: 102502-64-7.mol

Synonyms:(S)-2-(AdaMantan-1-yl)-2-aMinoacetic acid hydrochloride;(S)-Adamantylglycine Hydrochloride

Chemical Property of (S)-2-(AdaMantan-1-yl)-2-aMinoacetic acid hydrochloride

Chemical Property:

• PSA: 63.32000
• LogP: 3.11700
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(S)-AdamantylglycineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (S)-adamantylglycine is used to prepare saxagliptin (BMS-477118) as highly potent and long-acting and orally active dipeptidyl peptidase IV inhibitor for treatment of type 2 diabetes.

Technology Process of (S)-2-(AdaMantan-1-yl)-2-aMinoacetic acid hydrochloride

There total 16 articles about (S)-2-(AdaMantan-1-yl)-2-aMinoacetic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(R)-N-((S)-(adamantan-1-yl)(carboxy)methyl)-2-hydroxy-1-phenylethan-1-ammonium chloride → (S)-(+)-(adamant-1-yl)aminoacetic acid hydrochloride (102502-64-7)

Guidance literature:

With 20% palladium hydroxide-activated charcoal; hydrogen; acetic acid; at 20 ℃; for 96h;

DOI:10.1002/anie.201611067

Reference yield: 94.0%

(S)-2-(adamantan-1-yl)-2-aminoacetonitrile hydrochloride → (S)-(+)-(adamant-1-yl)aminoacetic acid hydrochloride (102502-64-7)

Guidance literature:

With hydrogenchloride; at 100 ℃; for 60h;

DOI:10.1039/c8cc06658b

Reference yield: 81.5%

C16H26N2OS → (S)-(+)-(adamant-1-yl)aminoacetic acid hydrochloride (102502-64-7)

Guidance literature:

With hydrogenchloride; acetic acid; In water; at 110 ℃; for 16h; Temperature;

upstream raw materials:

(S)-Acetylamino-adamantan-1-yl-acetic acid

1-Adamantanecarbaldehyde

(-)-(S)-N-[(1-adamantyl)phenylmethyl]acetamide

(-)-(S)-[(1-adamantyl)phenylmethyl]-4-methoxyphenylamine

Downstream raw materials:

S-PTAd

3-cyano-(αS)-α-(3-hydroxytricyclo[3.3.1.1^3,7]dec-1-yl)-β-oxo-(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-2-ethanecarbamic acid 1,1-dimethylethyl ester

saxagliptin

(S)-3-hydroxyadamantylglycine-D-cis-4,5-methanoprolinenitrile

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