AKOS B004258

Base Information

• Chemical Name: AKOS B004258
• CAS No.: 386299-28-1
• Molecular Formula: C₁₁H₁₀O₅
• Molecular Weight: 222.197
• Mol file: 386299-28-1.mol

Synonyms:AKOS B004258;RARECHEM AL BK 0254;(2E)-3-[4-(CARBOXYMETHOXY)PHENYL]-2-PROPENOIC ACID;2-PROPENOIC ACID, 3-[4-(CARBOXYMETHOXY)PHENYL]-, (2E)-;3-(4-CARBOXYMETHOXY-PHENYL)-ACRYLIC ACID;ART-CHEM-BB B004258

Chemical Property of AKOS B004258

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

99% ^*data from raw suppliers

(2E)-3-[4-(CARBOXYMETHOXY)PHENYL]-2-PROPENOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of AKOS B004258

There total 6 articles about AKOS B004258 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-[4-(methoxycarbonylmethoxy)phenyl]acrylate (100798-34-3) → 4-carboxymethoxy-trans-cinnamic acid (91345-17-4,386299-28-1)

Guidance literature:

With lithium hydroxide; water; In tetrahydrofuran; for 3h;

Reference yield:

methyl 4-hydroxycinnamate (3943-97-3) → 4-carboxymethoxy-trans-cinnamic acid (91345-17-4,386299-28-1)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide

2: LiOH; H₂O / tetrahydrofuran / 3 h

With lithium hydroxide; water; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-carboxymethoxy-trans-cinnamic acid (91345-17-4,386299-28-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH

2: sodium acetate

With sodium hydroxide; sodium acetate;

upstream raw materials:

acetic anhydride

(4-formylphenoxy)acetic acid

malonic acid

methyl 3-[4-(methoxycarbonylmethoxy)phenyl]acrylate

Downstream raw materials:

3-(4-methoxycarbonylmethoxy-phenyl)-propionic acid methyl ester

3-[4-(carboxymethoxy)phenyl]propionic acid