2-Boc-7-oxo-2-Azaspiro[4.4]nonane

Base Information

• Chemical Name: 2-Boc-7-oxo-2-Azaspiro[4.4]nonane
• CAS No.: 1319716-42-1
• Molecular Formula: C13H21NO3
• Molecular Weight: 239.315
• Mol file: 1319716-42-1.mol

Synonyms:2-Boc-7-oxo-2-Azaspiro[4.4]nonane;tert-butyl 7-oxo-2-azaspiro[4.4]nonane-2-carboxylate

Chemical Property of 2-Boc-7-oxo-2-Azaspiro[4.4]nonane

Chemical Property:

• Boiling Point: 348.6±25.0 °C(Predicted)
• PKA: -0.76±0.20(Predicted)
• PSA: 46.61000
• Density: 1.12±0.1 g/cm3(Predicted)
• LogP: 2.30450
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butyl7-Oxo-2-azaspiro[4.4]nonane-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: tert-Butyl 7-Oxo-2-azaspiro[4.4]nonane-2-carboxylate is a useful reagent for preparing inhibitors of the menin-MLL interaction.

Technology Process of 2-Boc-7-oxo-2-Azaspiro[4.4]nonane

There total 5 articles about 2-Boc-7-oxo-2-Azaspiro[4.4]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

tert-butyl 7-hydroxy-2-azaspiro[4.4]nonane-2-carboxylate (1319716-41-0) → tert-butyl 7-oxo-2-azaspiro[4.4]nonane-2-carboxylate (1319716-42-1)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

tert-butyl 3,3-diallyl-2-oxopyrrolidine-1-carboxylate (1319716-35-2) → tert-butyl 7-oxo-2-azaspiro[4.4]nonane-2-carboxylate (1319716-42-1)

Guidance literature:

Multi-step reaction with 3 steps

1: Grubbs catalyst first generation / dichloromethane / 20 °C

2: dimethylsulfide borane complex / 18 h / 20 °C

3: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane; acetonitrile / 0 - 20 °C / Molecular sieve

With Grubbs catalyst first generation; tetrapropylammonium perruthennate; dimethylsulfide borane complex; 4-methylmorpholine N-oxide; In dichloromethane; acetonitrile;

DOI:10.1016/j.tetlet.2011.06.020

Reference yield:

tert-butyl 1-oxo-2-azaspiro[4.4]nonan-7-ene-2-carboxylate (1319716-36-3) → tert-butyl 7-oxo-2-azaspiro[4.4]nonane-2-carboxylate (1319716-42-1)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylsulfide borane complex / 18 h / 20 °C

2: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane; acetonitrile / 0 - 20 °C / Molecular sieve

With tetrapropylammonium perruthennate; dimethylsulfide borane complex; 4-methylmorpholine N-oxide; In dichloromethane; acetonitrile;

DOI:10.1016/j.tetlet.2011.06.020

upstream raw materials:

tert-butyl 7-hydroxy-2-azaspiro[4.4]nonane-2-carboxylate

tert-butyl 3,3-diallyl-2-oxopyrrolidine-1-carboxylate

tert-butyl 1-oxo-2-azaspiro[4.4]nonan-7-ene-2-carboxylate

tert-butyl 2-oxopyrrolidine-1-carboxylate

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