3,4-Dihydro-2(1H)-isoquinolinyl(4-piperidinyl)-methanone hydrochloride

Base Information

• Chemical Name: 3,4-Dihydro-2(1H)-isoquinolinyl(4-piperidinyl)-methanone hydrochloride
• CAS No.: 73415-60-8
• Molecular Formula: C₁₅H₂₀N₂O*ClH
• Molecular Weight: 280.798
• Hs Code.: 2933990090
• Mol file: 73415-60-8.mol

Synonyms:3,4-Dihydro-2(1H)-isoquinolinyl(4-piperidinyl)-methanone hydrochloride

Chemical Property of 3,4-Dihydro-2(1H)-isoquinolinyl(4-piperidinyl)-methanone hydrochloride

Chemical Property:

• PSA: 32.34000
• LogP: 2.63960

Purity/Quality:

98%min ^*data from raw suppliers

3,4-Dihydro-2(1H)-isoquinolinyl(4-piperidinyl)-methanone hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-Dihydro-2(1H)-isoquinolinyl(4-piperidinyl)-methanone hydrochloride

There total 1 articles about 3,4-Dihydro-2(1H)-isoquinolinyl(4-piperidinyl)-methanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-(3,4-dihydro-1H-isoquinolin-2-ylcarbonyl)piperidine-1,4-dicarboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-1,1-dimethyl-undecyl ester (350716-59-5) → 5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-Heptadecafluoro-2-methyldodecan-2-ol (141183-94-0) + (3,4-dihydro-1H-isoquinolin-2-yl)-piperidin-4-yl-methanone; hydrochloride (73415-60-8)

Guidance literature:

With hydrogenchloride; In methanol; at 60 ℃; for 16h;

DOI:10.1021/jo010111w

Reference yield:

(3,4-dihydro-1H-isoquinolin-2-yl)-piperidin-4-yl-methanone; hydrochloride (73415-60-8) → C25H26N4O2

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 100 °C / Inert atmosphere

2: caesium carbonate / 1-methyl-pyrrolidin-2-one / 180 °C / Inert atmosphere; Microwave irradiation

With caesium carbonate; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2017.04.009

Reference yield:

(3,4-dihydro-1H-isoquinolin-2-yl)-piperidin-4-yl-methanone; hydrochloride (73415-60-8) → C25H25FN4O2

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 100 °C / Inert atmosphere

2: caesium carbonate / 1-methyl-pyrrolidin-2-one / 180 °C / Inert atmosphere; Microwave irradiation

With caesium carbonate; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2017.04.009

upstream raw materials:

4-(3,4-dihydro-1H-isoquinolin-2-ylcarbonyl)piperidine-1,4-dicarboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-1,1-dimethyl-undecyl ester

Refernces