AVP-786

Base Information

• Chemical Name: AVP-786
• CAS No.: 1079043-55-2
• Molecular Formula: C18H19D6NO
• Molecular Weight: 277.434170668
• Mol file: 1079043-55-2.mol

Synonyms:AVP-786;Deudextromethorphan;(9alpha,13alpha,14alpha)-3-(Methoxy-d3)-17-(methyl-d3)morphinan

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Chemical Property of AVP-786

Chemical Property:

• PSA: 12.47000
• LogP: 3.32130

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AVP-786

There total 12 articles about AVP-786 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.6%

[2H3]methyl 2-nitrobenzenesulfonate + (9S,13S,14S)-3-hydroxy-17-benzylmorphinane hydrobromide → [2H]-Dextromethorphan 3,17-d6 (1079043-55-2)

Guidance literature:

[²H₃]methyl 2-nitrobenzenesulfonate; (9S,13S,14S)-3-hydroxy-17-benzylmorphinane hydrobromide; With sodium t-butanolate; In N,N-dimethyl-formamide; at -10 ℃; for 2h;

[²H₃]methyl 2-nitrobenzenesulfonate; With sodium hydrogencarbonate; In acetonitrile; at 60 ℃; for 3h; Autoclave;

With palladium 10% on activated carbon; hydrogen; In water; acetonitrile; at 20 ℃; for 2.5h;

Reference yield: 93.0%

(9S,13S,14S)-3-hydroxy-17-benzylmorphinane hydrobromide + [2H3]methyl 4-nitrobenzenesulfonate (138240-30-9) → [2H]-Dextromethorphan 3,17-d6 (1079043-55-2)

Guidance literature:

(9S,13S,14S)-3-hydroxy-17-benzylmorphinane hydrobromide; [²H₃]methyl 4-nitrobenzenesulfonate; With sodium t-butanolate; In N,N-dimethyl-formamide; at 0 ℃; for 2h;

[²H₃]methyl 4-nitrobenzenesulfonate; With sodium hydrogencarbonate; sodium iodide; In acetonitrile; at 85 ℃; for 4h; Autoclave;

With palladium 10% on activated carbon; hydrogen; In water; acetonitrile; at 50 ℃; for 3h;

Reference yield: 92.6%

(9S,13S,14S)-3-hydroxy-17-benzylmorphinane hydrobromide + [2H3]methyl benzenesulfonate (120651-50-5) → [2H]-Dextromethorphan 3,17-d6 (1079043-55-2)

Guidance literature:

(9S,13S,14S)-3-hydroxy-17-benzylmorphinane hydrobromide; [²H₃]methyl benzenesulfonate; With sodium t-butanolate; In N,N-dimethyl-formamide; at 0 ℃; for 2h;

[²H₃]methyl benzenesulfonate; With sodium hydrogencarbonate; sodium iodide; In acetonitrile; at 85 ℃; for 4h; Autoclave;

With palladium 10% on activated carbon; hydrogen; In water; acetonitrile; at 50 ℃; for 3h;

upstream raw materials:

(+)-17-ethylcarbamate-3-d3-methoxy-(9α,13α,14α)-morphinan

[²H₃]methyl 4-nitrobenzenesulfonate

(+)-3-Methoxymorphinan hydrochloride

dextromethorphan