Technology Process of AVP-786
There total 12 articles about AVP-786 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
[2H3]methyl 2-nitrobenzenesulfonate; (9S,13S,14S)-3-hydroxy-17-benzylmorphinane hydrobromide;
With
sodium t-butanolate;
In
N,N-dimethyl-formamide;
at -10 ℃;
for 2h;
[2H3]methyl 2-nitrobenzenesulfonate;
With
sodium hydrogencarbonate;
In
acetonitrile;
at 60 ℃;
for 3h;
Autoclave;
With
palladium 10% on activated carbon; hydrogen;
In
water; acetonitrile;
at 20 ℃;
for 2.5h;
- Guidance literature:
-
(9S,13S,14S)-3-hydroxy-17-benzylmorphinane hydrobromide; [2H3]methyl 4-nitrobenzenesulfonate;
With
sodium t-butanolate;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 2h;
[2H3]methyl 4-nitrobenzenesulfonate;
With
sodium hydrogencarbonate; sodium iodide;
In
acetonitrile;
at 85 ℃;
for 4h;
Autoclave;
With
palladium 10% on activated carbon; hydrogen;
In
water; acetonitrile;
at 50 ℃;
for 3h;
- Guidance literature:
-
(9S,13S,14S)-3-hydroxy-17-benzylmorphinane hydrobromide; [2H3]methyl benzenesulfonate;
With
sodium t-butanolate;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 2h;
[2H3]methyl benzenesulfonate;
With
sodium hydrogencarbonate; sodium iodide;
In
acetonitrile;
at 85 ℃;
for 4h;
Autoclave;
With
palladium 10% on activated carbon; hydrogen;
In
water; acetonitrile;
at 50 ℃;
for 3h;
