6-BROMO-4-CHLORO-7-AZAINDOLE

Base Information

• Chemical Name: 6-BROMO-4-CHLORO-7-AZAINDOLE
• CAS No.: 1000340-64-6
• Molecular Formula: C7H4BrClN2
• Molecular Weight: 231.479
• Hs Code.: 2933990090
• Mol file: 1000340-64-6.mol

Synonyms:6-BROMO-4-CHLORO-7-AZAINDOLE;1H-Pyrrolo[2,3-b]pyridine, 6-broMo-4-chloro-;6-BroMo-4-chloro-1H-pyrrolo[2,3-b]pyridine

Chemical Property of 6-BROMO-4-CHLORO-7-AZAINDOLE

Chemical Property:

• PSA: 28.68000
• LogP: 2.97880

Purity/Quality:

99% ^*data from raw suppliers

6-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BROMO-4-CHLORO-7-AZAINDOLE

There total 3 articles about 6-BROMO-4-CHLORO-7-AZAINDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.5%

(6-bromo-4-chloro-1H-pyrrolo[2,3-b]pyridin-1-yl)(phenyl)methanone (1171896-08-4) → 6-bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine (1000340-64-6)

Guidance literature:

With sodium hydroxide; In methanol; water; at 20 ℃;

Reference yield:

4-chloro-7-azaindole (55052-28-3) → 6-bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine (1000340-64-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / tetrahydrofuran / 6 h

2: 1,1,1,3,3,3-hexamethyl-disilazane / tetrahydrofuran / 3.5 h / 20 - 30 °C

3: sodium hydroxide / water; methanol / 20 °C

With 3-chloro-benzenecarboperoxoic acid; 1,1,1,3,3,3-hexamethyl-disilazane; sodium hydroxide; In tetrahydrofuran; methanol; water;

Reference yield:

4-Chloro-1H-pyrrolo<2,3-b>pyridine 7-oxide (74420-03-4) → 6-bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine (1000340-64-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,1,1,3,3,3-hexamethyl-disilazane / tetrahydrofuran / 3.5 h / 20 - 30 °C

2: sodium hydroxide / water; methanol / 20 °C

With 1,1,1,3,3,3-hexamethyl-disilazane; sodium hydroxide; In tetrahydrofuran; methanol; water;

upstream raw materials:

(6-bromo-4-chloro-1H-pyrrolo[2,3-b]pyridin-1-yl)(phenyl)methanone

4-chloro-7-azaindole

4-Chloro-1H-pyrrolo<2,3-b>pyridine 7-oxide

Refernces

• 1、 -. "Pyrrolopyrimidines and Pyrrolopyridines". Page/Page column 47. . Retrieved 2009/07/25.