RaceMic 2-Aza-bicyclo[2.2.2]octane-2,6-dicarboxylic acid 2-tert-butyl ester

Base Information

• Chemical Name: RaceMic 2-Aza-bicyclo[2.2.2]octane-2,6-dicarboxylic acid 2-tert-butyl ester
• CAS No.: 1250997-05-7
• Molecular Formula: C₁₃H₂₁NO₄
• Molecular Weight: 255.314
• Hs Code.: 2933990090
• Mol file: 1250997-05-7.mol

Synonyms:RaceMic 2-Aza-bicyclo[2.2.2]octane-2,6-dicarboxylic acid 2-tert-butyl ester;2-Boc-2-azabicyclo[2.2.2]octane-6-carboxylic acid;2-(tert-Butoxycarbonyl)-2-azabicyclo[2.2.2]octane-6-carboxylic acid;2-Aza-bicyclo[2.2.2]octane-2,6-dicarboxylic acid 2-tert-butyl ester

Chemical Property of RaceMic 2-Aza-bicyclo[2.2.2]octane-2,6-dicarboxylic acid 2-tert-butyl ester

Chemical Property:

• Boiling Point: 386.0±25.0 °C(Predicted)
• PKA: 4.50±0.20(Predicted)
• PSA: 66.84000
• Density: 1.196±0.06 g/cm3(Predicted)
• LogP: 2.04450

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(tert-Butoxycarbonyl)-2-azabicyclo[2.2.2]octane-6-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of RaceMic 2-Aza-bicyclo[2.2.2]octane-2,6-dicarboxylic acid 2-tert-butyl ester

There total 1 articles about RaceMic 2-Aza-bicyclo[2.2.2]octane-2,6-dicarboxylic acid 2-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-tert-butyl 6-methyl (1R*,4S*)-2-azabicyclo[2.2.2]octane-2,6-dicarboxylate → (1R*,4S*,6R*)-2-(tert-Butoxycarbonyl)-2-azabicyclo[2.2.2]octane-6-carboxylic Acid (1250997-05-7)

Guidance literature:

2-tert-butyl 6-methyl (1R*,4S*)-2-azabicyclo[2.2.2]octane-2,6-dicarboxylate; With water; sodium hydroxide; In methanol; at 20 ℃; for 3h;

With hydrogenchloride; water; In methanol;

DOI:10.1016/j.bmc.2009.06.042

Reference yield: 49.0%

(1R*,4S*,6R*)-2-(tert-Butoxycarbonyl)-2-azabicyclo[2.2.2]octane-6-carboxylic Acid (1250997-05-7) + 4-(isopropoxy)aniline (7664-66-6) → tert-butyl (1R*,4S*,6R*)-(+/-)-6-{[4-(propan-2-yloxy)phenyl]carbamoyl}-2-azabicyclo[2.2.2]octane-2-carboxylate

Guidance literature:

With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 20 ℃; for 14h;

DOI:10.1016/j.bmc.2009.06.042

Refernces