Chemical Property of 2,2-diphenyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamide
Chemical Property:
- PKA:7.03±0.10(Predicted)
- PSA：124.78000
- Density:1.409±0.06 g/cm3(Predicted)
- LogP:5.94130
- Storage Temp.:room temp
- Solubility.:DMSO: soluble20mg/mL, clear
- XLogP3:3.2
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:7
- Exact Mass:449.08678382
- Heavy Atom Count:31
- Complexity:659
- Purity/Quality:
-
99%, *data from raw suppliers
ICA 121431 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xn
- Statements:
22-36
- Safety Statements:
26
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)NC4=NC=CS4
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Description
ICA 121431 is a voltage-gated sodium channel (Nav) blocker that selectively blocks Nav1.1 and Nav1.3 over Nav1.4, and Nav1.5-1.8 channels (IC50s = <20, 19, 240, and >10,000 nM, respectively). It induces a concentration-dependent hyperpolarizing shift in voltage dependence of inactivation of Nav1.3 channels at a concentration 1 μM but has no effect on resting channels. Substitution of the Nav1.3 domain IV voltage-sensor domain (VSD4) with the Nav1.5 VSD4 reduces ICA 121431 potency by approximately 500-fold.
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Uses
ICA 121431 is a voltage-gated sodium (Nav) channel inhibitor.
