t-Butyl 2-borono-4-methylbenzenesulfonamide

Base Information

• Chemical Name: t-Butyl 2-borono-4-methylbenzenesulfonamide
• CAS No.: 183000-60-4
• Molecular Formula: C11H18BNO4S
• Molecular Weight: 271.14092
• Hs Code.: 2935009090
• Mol file: 183000-60-4.mol

Synonyms:2-(t-Butylsulfamoyl)-5-methylphenylboronic acid;t-Butyl 2-borono-4-methylbenzenesulfonamide;(2-(N-(tert-Butyl)sulfaMoyl)-5-Methylphenyl)boronic acid

Chemical Property of t-Butyl 2-borono-4-methylbenzenesulfonamide

Chemical Property:

• PSA: 95.01000
• LogP: 1.22330
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-(t-Butylsulfamoyl)-5-methylphenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of t-Butyl 2-borono-4-methylbenzenesulfonamide

There total 3 articles about t-Butyl 2-borono-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Triisopropyl borate (5419-55-6) + N-t-butyl-p-toluenesulfonamide (2849-81-2) → 2-t-Butylaminosulfonyl-5-methyl-benzeneboronic acid (183000-60-4)

Guidance literature:

N-t-butyl-p-toluenesulfonamide; With n-butyllithium; In tetrahydrofuran; at -78 - -20 ℃; for 4h; Inert atmosphere;

Triisopropyl borate; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; Inert atmosphere;

DOI:10.1016/j.bmc.2013.10.017

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 2-t-Butylaminosulfonyl-5-methyl-benzeneboronic acid (183000-60-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane / 8 h / 20 °C / Cooling with ice

2.1: n-butyllithium / tetrahydrofuran / 4 h / -78 - -20 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

2.3: Inert atmosphere

With n-butyllithium; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmc.2013.10.017

Reference yield:

→ 2-t-Butylaminosulfonyl-5-methyl-benzeneboronic acid (183000-60-4)

Guidance literature:

upstream raw materials:

p-toluenesulfonyl chloride

Triisopropyl borate

N-t-butyl-p-toluenesulfonamide

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