5,6-Dihydro-5-(p-tolylsulfonyl)-7H-dibenz[b,d]azepin-7-one

Base Information

Chemical Name:5,6-Dihydro-5-(p-tolylsulfonyl)-7H-dibenz[b,d]azepin-7-one
CAS No.:24127-35-3
Molecular Formula:C21H17NO3S
Molecular Weight:363.437
Hs Code.:2933990090
Mol file:24127-35-3.mol

Synonyms:5,6-Dihydro-5-(p-tolylsulfonyl)-7H-dibenz[b,d]azepin-7-one

Suppliers and Price of 5,6-Dihydro-5-(p-tolylsulfonyl)-7H-dibenz[b,d]azepin-7-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 5,6-Dihydro-5-(p-tolylsulfonyl)-7H-dibenz[b,d]azepin-7-one

Chemical Property:

PSA：62.83000
LogP:5.19940

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5,6-Dihydro-5-(p-tolylsulfonyl)-7H-dibenz[b,d]azepin-7-one

There total 12 articles about 5,6-Dihydro-5-(p-tolylsulfonyl)-7H-dibenz[b,d]azepin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 94870-32-3
N-[1,1’-biphenyl]-2-yl-N-[(4-methylphenyl)sulfonyl]glycine

: 24127-35-3
7-Oxo-5-(p-toluolsulfonyl)-6,7-dihydro-5H-dibenzazepin

Guidance literature:: N-[1,1’-biphenyl]-2-yl-N-[(4-methylphenyl)sulfonyl]glycine; With thionyl chloride; for 1h; Reflux; Inert atmosphere;

With aluminum (III) chloride; In dichloromethane; at -78 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/acs.joc.1c00594

Reference yield:

: 100027-22-3
N-Biphenylyl-⁽²⁾-N-p-toluol-sulfonyl-glycin-chlorid

: 24127-35-3
7-Oxo-5-(p-toluolsulfonyl)-6,7-dihydro-5H-dibenzazepin

Guidance literature:: With aluminum (III) chloride; In chloroform; at -75 - 20 ℃; Cooling with acetone-dry ice;

Reference yield:

: 82617-45-6
3-methyl-2-nitro-[1,1 '-biphenyl]

: 24127-35-3
7-Oxo-5-(p-toluolsulfonyl)-6,7-dihydro-5H-dibenzazepin

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen; palladium 10% on activated carbon / methanol; tetrahydrofuran / 19 h / 20 °C

2.1: pyridine / 23 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 20 °C / Inert atmosphere

3.2: 1 h / 20 °C / Inert atmosphere

4.1: sodium hydroxide / water; methanol / 2 h / 20 °C / Inert atmosphere

5.1: thionyl chloride / 1 h / Reflux; Inert atmosphere

5.2: 1 h / -78 - 20 °C / Inert atmosphere

With pyridine; thionyl chloride; palladium 10% on activated carbon; hydrogen; sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; mineral oil; 5.2: |Friedel-Crafts Acylation;
DOI:10.1021/acs.joc.1c00594