(2S,3R)-benzyl 3-(tert-butoxycarbonyl)-2-methylpiperidine-1-carboxylate

Base Information

• Chemical Name: (2S,3R)-benzyl 3-(tert-butoxycarbonyl)-2-methylpiperidine-1-carboxylate
• CAS No.: 1044563-67-8
• Molecular Formula: C19H27NO4
• Molecular Weight: 348.442
• Mol file: 1044563-67-8.mol

Synonyms:(2S,3R)-benzyl 3-(tert-butoxycarbonyl)-2-methylpiperidine-1-carboxylate;1-benzyl 3-tert-butyl 2-Methylpiperidine-1,3-dicarboxylate;(2S,3R)-1-Benzyl 3-tert-butyl 2-Methylpiperidine-1,3-dicarboxylate

Chemical Property of (2S,3R)-benzyl 3-(tert-butoxycarbonyl)-2-methylpiperidine-1-carboxylate

Chemical Property:

• PSA: 55.84000
• LogP: 3.70330
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(2S,3R)-1-Benzyl3-tert-butyl2-methylpiperidine-1,3-dicarboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2S,3R)-benzyl 3-(tert-butoxycarbonyl)-2-methylpiperidine-1-carboxylate

There total 5 articles about (2S,3R)-benzyl 3-(tert-butoxycarbonyl)-2-methylpiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

(R)-tert-butyl 2-methylpiperidin-3-ylcarbamate (1791402-58-8) + benzyl chloroformate (501-53-1,94274-21-2) → (2R,3R)-benzyl 3-(tert-butoxycarbonylamino)-2-methylpiperidine-1-carboxylate (1044563-65-6) + (25,3R)-benzyl 3-(tert-butoxycarbonylamino)-2-methylpiperidine-1-carboxylate (1044563-67-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 35h;

Reference yield:

(R)-Nδ-benzyloxycarbonyl-Nα-(tert-butoxycarbonyl)-ornithine (2480-93-5,16937-92-1) → (2R,3R)-benzyl 3-(tert-butoxycarbonylamino)-2-methylpiperidine-1-carboxylate (1044563-65-6) + (25,3R)-benzyl 3-(tert-butoxycarbonylamino)-2-methylpiperidine-1-carboxylate (1044563-67-8)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 20 °C

2: tetrahydrofuran / 0.5 h / -30 - 0 °C

3: palladium 10% on activated carbon; hydrogen / isopropyl alcohol / 12 h / 2585.81 Torr

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 35 h / 0 °C

With hydrogenchloride; palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; isopropyl alcohol; acetonitrile;

Reference yield:

(R)-6-(benzyloxycarbonylamino)-3-(tert-butoxycarbonylamino)-2-hexanone → (2R,3R)-benzyl 3-(tert-butoxycarbonylamino)-2-methylpiperidine-1-carboxylate (1044563-65-6) + (25,3R)-benzyl 3-(tert-butoxycarbonylamino)-2-methylpiperidine-1-carboxylate (1044563-67-8)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / isopropyl alcohol / 12 h / 2585.81 Torr

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 35 h / 0 °C

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In dichloromethane; isopropyl alcohol;

upstream raw materials:

(R)-tert-butyl 2-methylpiperidin-3-ylcarbamate

benzyl chloroformate

(R)-Nδ-benzyloxycarbonyl-Nα-(tert-butoxycarbonyl)-ornithine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1044563-67-8 (2S,3R)-benzyl 3-(tert-butoxycarbonyl)-2-methylpiperidine-1-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send