3-[2-(Dimethylamino)ethoxy]-4-methoxyaniline

Base Information

• Chemical Name: 3-[2-(Dimethylamino)ethoxy]-4-methoxyaniline
• CAS No.: 170229-68-2
• Molecular Formula: C₁₁H₁₈N₂O₂
• Molecular Weight: 210.276
• European Community (EC) Number: 833-953-3
• Nikkaji Number: J1.292.220E
• ChEMBL ID: CHEMBL277147
• Mol file: 170229-68-2.mol

Synonyms:3-[2-(dimethylamino)ethoxy]-4-methoxyaniline;170229-68-2;N-[2-(5-amino-2-methoxyphenoxy)ethyl]-N,N-dimethylamine;CHEMBL277147;SCHEMBL1220219;WFMRAKZOFYATRY-UHFFFAOYSA-N;VGA22968;AKOS000142382;BS-33881;3-(2-Dimethylaminoethoxy)-4-methoxyaniline;FT-0769949;EN300-36515;3-(2-Dimethylamino-ethoxy)-4-methoxy-phenylamine;3-{[2-(dimethylamino)ethyl]oxy}-4-(methyloxy)aniline;Z239873248

Chemical Property of 3-[2-(Dimethylamino)ethoxy]-4-methoxyaniline

Chemical Property:

• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 210.136827821
• Heavy Atom Count: 15
• Complexity: 176

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN(C)CCOC1=C(C=CC(=C1)N)OC

Technology Process of 3-[2-(Dimethylamino)ethoxy]-4-methoxyaniline

There total 2 articles about 3-[2-(Dimethylamino)ethoxy]-4-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-<2-(dimethylamino)ethoxy>-4-nitroanisole (170229-67-1) → 3-[2-(dimethylamino)ethoxy]-4-methoxyaniline (170229-68-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; under 2585.81 Torr;

Reference yield:

5-nitroguaiacol (636-93-1) → 3-[2-(dimethylamino)ethoxy]-4-methoxyaniline (170229-68-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / K₂CO₃ / acetone; H₂O / 10 h / Heating

2: 95 percent / H₂ / 10 percent Pd/C / ethanol / Ambient temperature

With hydrogen; potassium carbonate; palladium on activated charcoal; In ethanol; water; acetone;

DOI:10.1021/jm970457s

Reference yield: 43.0%

3-[2-(dimethylamino)ethoxy]-4-methoxyaniline (170229-68-2) + 2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-biphenyl-4-carbonyl chloride (165381-86-2) → SB 216641 (170230-39-4)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; Ambient temperature;

DOI:10.1021/jm970457s

upstream raw materials:

3-<2-(dimethylamino)ethoxy>-4-nitroanisole

5-nitroguaiacol

Downstream raw materials:

N-<3-<2-(dimethylamino)ethoxy>-4-methoxyphenyl>aminoacetaldehyde dimethyl acetal

SB 216641

N-(3,4-dichloro-phenyl)-N'-[3-(2-dimethylamino-ethoxy)-4-methoxy-phenyl]-ethane-1,2-diamine

N-[3-[2-[bis(1-methylethyl)amino]ethoxy]-4-methoxyphenyl]-5-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxamide