(S)-2-(2-AMINO-5-CHLOROPHENYL)-4-CYCLOPROPYL-1,1,1-TRIFLUOROBUT-3-YN-2-OL

Base Information

• Chemical Name: (S)-2-(2-AMINO-5-CHLOROPHENYL)-4-CYCLOPROPYL-1,1,1-TRIFLUOROBUT-3-YN-2-OL
• CAS No.: 154598-58-0
• Molecular Formula: C₁₃H₁₁ClF₃NO
• Molecular Weight: 289.685
• Mol file: 154598-58-0.mol

Synonyms:(S)-2-(2-AMINO-5-CHLOROPHENYL)-4-CYCLOPROPYL-1,1,1-TRIFLUOROBUT-3-YN-2-OL

Chemical Property of (S)-2-(2-AMINO-5-CHLOROPHENYL)-4-CYCLOPROPYL-1,1,1-TRIFLUOROBUT-3-YN-2-OL

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(2-AMINO-5-CHLOROPHENYL)-4-CYCLOPROPYL-1,1,1-TRIFLUOROBUT-3-YN-2-OL

There total 48 articles about (S)-2-(2-AMINO-5-CHLOROPHENYL)-4-CYCLOPROPYL-1,1,1-TRIFLUOROBUT-3-YN-2-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

Cyclopropylacetylene (6746-94-7) + 1-(2-amino-5-chloro-phenyl)-2,2,2-trifluoro-ethanone (154598-53-5) → (2S)-2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol (209414-27-7,927812-33-7,154598-58-0)

Guidance literature:

With (1R,2S)-N-pyrrolidinyl norephedrine; dimethyl zinc(II); In toluene; for 1h;

With methanol; In toluene; for 0.5h;

Cyclopropylacetylene; 1-(2-amino-5-chloro-phenyl)-2,2,2-trifluoro-ethanone; With butyl magnesium bromide; more than 3 stages; Product distribution / selectivity;

Reference yield: 96.0%

1-(2-amino-5-chloro-phenyl)-2,2,2-trifluoro-ethanone (154598-53-5) + cyclopropylacetylene magnesium chloride (216006-64-3) → (2S)-2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol (209414-27-7,927812-33-7,154598-58-0)

Guidance literature:

1-(2-amino-5-chloro-phenyl)-2,2,2-trifluoro-ethanone; cyclopropylacetylene magnesium chloride; With methanol; (1R,2S)-N-pyrrolidinyl norephedrine; dimethyl zinc(II); In toluene; at 20 ℃; for 9h;

With citric acid; In water; toluene; Product distribution / selectivity;

Reference yield: 95.0%

1-(2-amino-5-chloro-phenyl)-2,2,2-trifluoro-ethanone (154598-53-5) + cyclopropyl acetylenyllithium (201218-09-9) → (αR)-2-amino-5-chloro-α-(2-cyclopropylethynyl)-α-(trifluoromethyl)benzenemethanol (927812-33-7,154598-58-0) + (2S)-2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol (209414-27-7,927812-33-7,154598-58-0)

Guidance literature:

1-(2-amino-5-chloro-phenyl)-2,2,2-trifluoro-ethanone; cyclopropyl acetylenyllithium; With methanol; (+/-)-erythro-2-dibenzylamino-1-phenyl-propanol-⁽¹⁾; dimethyl zinc(II); In toluene; for 9h;

With citric acid; In water; toluene; Product distribution / selectivity;

upstream raw materials:

Cyclopropylacetylene

1-(2-amino-5-chloro-phenyl)-2,2,2-trifluoro-ethanone

cyclopropyl acetylenyllithium

2-cyclopropylethynyl-magnesium bromide

Downstream raw materials:

3-bromo-6-chloro-2-cyclopropyl-4-(trifluoromethyl)quinoline

6-chloro-2-cyclopropyl-4-(trifluoromethyl)quinoline

3,6-dichloro-2-cyclopropyl-4-(trifluoromethyl)quinoline

(S)-N-(4-chloro-2-(4-cyclopropyl-1,1,1-trifluoro-2-hydroxybut-3-yn-2-yl)phenyl)pivalamide