5-Iodo-1,3-dihydro-benzimidazol-2-one

Base Information

• Chemical Name: 5-Iodo-1,3-dihydro-benzimidazol-2-one
• CAS No.: 40644-14-2
• Molecular Formula: C7H5IN2O
• Molecular Weight: 260.034
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID40476982
• Nikkaji Number: J2.327.502C
• Wikidata: Q82308985
• Mol file: 40644-14-2.mol

Synonyms:40644-14-2;5-IODO-1,3-DIHYDRO-BENZIMIDAZOL-2-ONE;5-IODO-1,3-DIHYDRO-BENZOIMIDAZOL-2-ONE;5-iodo-1,3-dihydrobenzimidazol-2-one;1,3-Dihydro-5-iodo-2H-benzimidazol-2-one;5-IODO-2,3-DIHYDRO-1H-1,3-BENZODIAZOL-2-ONE;5-IODO-2-BENZIMIDAZOLINONE;SCHEMBL3348374;SCHEMBL4382993;SCHEMBL18745954;SCHEMBL20146766;DTXSID40476982;MCYVBTDFXAZDHA-UHFFFAOYSA-N;AMY39218;AKOS022193569;AB21858;5-iodo-1,3-dihydrobenzo[d]imidazol-2-one;EN300-646082;5-iodo-1,3-dihydro-2H-1,3-benzimidazol-2-one;5-Iodo-1,3-dihydro-2H-1,3-benzimidazole-2-one

Chemical Property of 5-Iodo-1,3-dihydro-benzimidazol-2-one

Chemical Property:

• PSA: 48.65000
• LogP: 1.46080
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 259.94466
• Heavy Atom Count: 11
• Complexity: 185

Purity/Quality:

98%min ^*data from raw suppliers

5-Iodo-1,3-dihydro-benzoimidazol-2-one >97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=C1I)NC(=O)N2

Technology Process of 5-Iodo-1,3-dihydro-benzimidazol-2-one

There total 3 articles about 5-Iodo-1,3-dihydro-benzimidazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

4-iodo-2-nitroaniline (20691-72-9) + benzene-1,3,5-triyl triformate → 5-iodo-1,3-dihydro-2H-1,3-benzimidazol-2-one (40644-14-2)

Guidance literature:

With selenium; triethylamine; In N,N-dimethyl-formamide; at 120 ℃; Inert atmosphere; Sealed tube;

DOI:10.1002/ejoc.201801739

Reference yield:

4-iodo-2-nitroaniline (20691-72-9) → 5-iodo-1,3-dihydro-2H-1,3-benzimidazol-2-one (40644-14-2)

Guidance literature:

Multi-step reaction with 2 steps

1: stannous chloride hydrate; hydrogenchloride / water / 3 h / 25 - 65 °C / Inert atmosphere

2: tetrahydrofuran / 18 h / 25 °C / Inert atmosphere

With hydrogenchloride; stannous chloride hydrate; In tetrahydrofuran; water;

DOI:10.1002/chem.201601505

Reference yield:

3-fluorobenzene-1,2-diamine (18645-88-0) → 5-iodo-1,3-dihydro-2H-1,3-benzimidazol-2-one (40644-14-2) + 4-fluoro-1,3-dihydro-2H-1,3-benzimidazole-2-one (256519-10-5)

Guidance literature:

upstream raw materials:

3-fluorobenzene-1,2-diamine

4-iodo-2-nitroaniline

Downstream raw materials:

2-chloro-6-iodo-1H-benzimidazole

2-chloro-5-iodo-1H-benzimidazole