1,4,5,6-TETRAHYDRO-PYRIDINE-3-CARBONITRILE

Base Information

Chemical Name:1,4,5,6-TETRAHYDRO-PYRIDINE-3-CARBONITRILE
CAS No.:7492-87-7
Molecular Formula:C₆H₈N₂
Molecular Weight:108.143
Hs Code.:
Mol file:7492-87-7.mol

Synonyms:1,4,5,6-TETRAHYDRO-PYRIDINE-3-CARBONITRILE

Suppliers and Price of 1,4,5,6-TETRAHYDRO-PYRIDINE-3-CARBONITRILE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1,4,5,6-TETRAHYDROPYRIDINE-3-CARBONITRILE 95.00%
1G
$ 669.90

Total 3 raw suppliers

Chemical Property of 1,4,5,6-TETRAHYDRO-PYRIDINE-3-CARBONITRILE

Chemical Property:

Vapor Pressure:0.0922mmHg at 25°C
Melting Point:38-39 °C
Boiling Point:224.2°C at 760 mmHg
PKA:6.56±0.40(Predicted)
Flash Point:89.4°C
PSA：35.82000
Density:1.04g/cm³
LogP:1.10608

Purity/Quality:: 1,4,5,6-TETRAHYDROPYRIDINE-3-CARBONITRILE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

General Description 1,4,5,6-TETRAHYDRO-PYRIDINE-3-CARBONITRILE (also referred to as 3-cyano-1,4,5,6-tetrahydropyridine) is a key intermediate in stereoselective conjugate addition reactions, particularly in the formation of indolizidine and quinolizidine derivatives, where the nitrile group exhibits a thermodynamic preference for the axial orientation. It is also utilized in synthetic routes for pharmaceutical intermediates, such as the side chain of anti-Pseudomonas aeruginosa cephalosporin FR259647, demonstrating its versatility in regioselective enamine exchange and intramolecular cyclization reactions.

Technology Process of 1,4,5,6-TETRAHYDRO-PYRIDINE-3-CARBONITRILE

There total 3 articles about 1,4,5,6-TETRAHYDRO-PYRIDINE-3-CARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 100-54-9,121697-66-3,1232169-17-3,68271-95-4
pyridine-3-carbonitrile

: 7492-87-7
1,4,5,6-tetrahydropyridine-3-carbonitrile

Guidance literature:: With C₄₆H₄₉CoN₃P₄⁽²⁺⁾*2BF₄^(1-); hydrogen; potassium hydroxide; In isopropyl alcohol; acetonitrile; at 100 ℃; for 48h; under 22801.5 Torr; chemoselective reaction; Autoclave; Glovebox;
DOI:10.1021/jacs.9b11070