fomivirsen

Base Information

Synonyms:Deoxyribonucleicacid, d(P-thio)(G-C-G-T-T-T-G-C-T-C-T-T-C-T-T-C-T-T-G-C-G), eicosasodium salt;Fomivirsen sodium; Vitravene

Suppliers and Price of fomivirsen

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Total 2 raw suppliers

Chemical Property of fomivirsen

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

FOMIVIRSEN SODIUM 95.00% ^*data from reagent suppliers

Safty Information:

Useful:

Description Fomivirsen Sodium was launched as Vitravene in the US and is indicated for the local treatment of cytomegalovirus (CMV)-induced retinitis in AIDS patients. It consists of a phosphorothioate oligonucleotide (PS) comprised of a sequence of 21 nucleotides. Fomivirsen is synthesized using solid-phase phosphoramidite chemistry. Fomivirsen inhibits human CMV replication by a antisense mechanism : it targets an immediate early mRNA of cytomegalovirus, inhibiting the expression of two regulatory proteins. Fomivirsen was the most advanced first-generation PS drug candidate in human clinical trials and was the first agent based on antisense technology to reach the market. In normal human dermal fibroblast cells, Fomivirsen inhibited AD169 human CMV replication by more than 90%, at a concentration of 5μM ; it showed greater hCMV replication inhibitor properties than ganciclovir in several experimental models.

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