Ledipasvir interMediate

Base Information

Chemical Name:Ledipasvir interMediate
CAS No.:1256388-47-2
Molecular Formula:C15H17NO4
Molecular Weight:275.304
Hs Code.:
Mol file:1256388-47-2.mol

Synonyms:Ledipasvir interMediate;(S)-5-((Benzyloxy)carbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid;(6S)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(phenylmethyl) ester;N-Cbz-4-cyclopropyl-(L)-proline

Suppliers and Price of Ledipasvir interMediate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
(S)-5-((benzyloxy)carbonyl)-5-azaspiro[2.4]heptane-6-carboxylicacid 95%
1g
$ 744.00

Alichem
(S)-5-Cbz-5-azaspiro[2.4]heptane-6-carboxylicacid
1g
$ 820.26

Acrotein
(S)-5-Cbz-5-azaspiro[2.4]heptane-6-carboxylicacid 97%
5g
$ 412.50

ACHEMBLOCK
(6S)-5-[(benzyloxy)carbonyl]-5-azaspiro[2.4]heptane-6-carboxylicacid 97%
5G
$ 375.00

ACHEMBLOCK
(6S)-5-[(benzyloxy)carbonyl]-5-azaspiro[2.4]heptane-6-carboxylicacid 97%
1G
$ 125.00

Total 19 raw suppliers

Chemical Property of Ledipasvir interMediate

Chemical Property:

PSA：66.84000
LogP:2.20020

Purity/Quality:

97% ^*data from raw suppliers

(S)-5-((benzyloxy)carbonyl)-5-azaspiro[2.4]heptane-6-carboxylicacid 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Ledipasvir interMediate

There total 9 articles about Ledipasvir interMediate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: (6S)-5-(benzyloxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid R-α-methylbenzylamine salt

: 1256388-47-2
(S)-5-((benzyloxy)carbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid

Guidance literature:: With hydrogenchloride; In Isopropyl acetate; water; at 0 ℃; pH=3 - 4;

Reference yield: 75.0%

: 1129634-44-1,1454843-77-6,1454843-78-7
(6S)-5-[(tert-butoxy)carbonyl]-5-azaspiro[2.4]heptane-6-carboxylic acid

: 501-53-1,94274-21-2
benzyl chloroformate

: 1256388-47-2
(S)-5-((benzyloxy)carbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid

Guidance literature:: (6S)-5-[(tert-butoxy)carbonyl]-5-azaspiro[2.4]heptane-6-carboxylic acid; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

benzyl chloroformate; With sodium hydrogencarbonate; In water; at 0 - 20 ℃;