2-Phthalimidoacetamide

Base Information

• Chemical Name: 2-Phthalimidoacetamide
• CAS No.: 4935-96-0
• Molecular Formula: C10H8N2O3
• Molecular Weight: 204.1821
• Hs Code.: 2925190090
• European Community (EC) Number: 653-844-2
• NSC Number: 45851
• DSSTox Substance ID: DTXSID90197776
• Nikkaji Number: J68.610G
• Wikidata: Q83070546
• Mol file: 4935-96-0.mol

Synonyms:4935-96-0;2-Phthalimidoacetamide;N-Phthalylglycinamide;N-Phthaloylglycinamide;Acetamide, 2-phthalimido-;2-(1,3-Dioxoisoindolin-2-yl)acetamide;Phthalimide, N-(carbamoylmethyl)-;NSC 45851;2-(1,3-dioxoisoindol-2-yl)acetamide;BRN 0384143;2-ISOINDOLINEACETAMIDE, 1,3-DIOXO-;2H-Isoindole-2-acetamide, 1,3-dihydro-1,3-dioxo-;2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)acetamide;n-Phthaloylglycineamide;2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide;2H-Isoindole-2-acetamide, 1,3-dihydro-1,3-dioxo- (9CI);phthalimidoacetic acid amide;Oprea1_453186;SCHEMBL3281797;2-Isoindolineacetamide,3-dioxo-;DTXSID90197776;HMS1760D07;NSC45851;NSC-45851;STL576993;AKOS001061515;LS-84689;EU-0017591;2H-Isoindole-2-acetamide,3-dihydro-1,3-dioxo-;Z18271715

Chemical Property of 2-Phthalimidoacetamide

Chemical Property:

• Vapor Pressure: 7.58E-08mmHg at 25°C
• Boiling Point: 437.3°Cat760mmHg
• Flash Point: 218.2°C
• PSA: 80.47000
• Density: 1.448g/cm³
• LogP: 0.40610
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 204.05349212
• Heavy Atom Count: 15
• Complexity: 303

Purity/Quality:

99% ^*data from raw suppliers

N-Phthaloylglycineamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=O)N(C2=O)CC(=O)N

Technology Process of 2-Phthalimidoacetamide

There total 13 articles about 2-Phthalimidoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-Carbamoylmethyl-2-(pyrrolidine-1-carbonyl)-benzamide (135382-89-7) → 2-phthalimidoacetamide (4935-96-0)

Guidance literature:

With hydrogenchloride; In methanol; at 25 ℃;

DOI:10.1016/S0040-4039(00)92691-1

Reference yield: 85.0%

N-phthaloylglycine (4702-13-0) → 2-phthalimidoacetamide (4935-96-0)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonium chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1016/S0040-4039(99)00245-2

Reference yield: 82.0%

N-phthaloylglycine chloride (6780-38-7) → 2-phthalimidoacetamide (4935-96-0)

Guidance literature:

With ammonia; In acetonitrile; for 1h; Ambient temperature;

DOI:10.1007/BF00765906

upstream raw materials:

phthalic anhydride

2-aminoacetonitrile hydrochloride

N-(cyanomethyl)phthalimide

N-phthaloylglycine chloride

Downstream raw materials:

phthalimide

4-hydroxy-1(2H)-isoquinolone-3-carboxylic acid ethyl ester

Refernces

• 1、 Cizmecioglu, Murat,Pabuccuoglu, Varol,Ballar, Petek,Pabuccuoglu, Aysun,Soyer, Zeynep. "Synthesis and screening of cyclooxygenase inhibitory activity of some 1,3-dioxoisoindoline derivatives". experimental part. p. 186 - 190. Retrieved 2011/10/10.
• 2、 Casimir,Guichard,Briand. "Ultrasound and ZnCl2 promoted synthesis of phthaloyl derivatives of α-amino carboxamides". . p. 75 - 80. Retrieved 2007/10/03.