3-bromo-6-methyl-1H-pyrrolo[3,2-b]pyridine

Base Information

Chemical Name:3-bromo-6-methyl-1H-pyrrolo[3,2-b]pyridine
CAS No.:1190323-01-3
Molecular Formula:C8H7BrN2
Molecular Weight:211.05858
Hs Code.:
DSSTox Substance ID:DTXSID201268132
Mol file:1190323-01-3.mol

Synonyms:3-bromo-6-methyl-1H-pyrrolo[3,2-b]pyridine;1190323-01-3;1H-Pyrrolo[3,2-b]pyridine, 3-bromo-6-methyl-;3-BROMO-6-METHYL-4-AZAINDOLE;DTXSID201268132

Suppliers and Price of 3-bromo-6-methyl-1H-pyrrolo[3,2-b]pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemcia Scientific
3-Bromo-6-methyl-1H-pyrrolo[3,2-b]pyridine 95%
1 G
$ 495.00

Total 2 raw suppliers

Chemical Property of 3-bromo-6-methyl-1H-pyrrolo[3,2-b]pyridine

Chemical Property:

PSA：28.68000
LogP:2.63380
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:209.97926
Heavy Atom Count:11
Complexity:151

Purity/Quality:

98% ^*data from raw suppliers

3-Bromo-6-methyl-1H-pyrrolo[3,2-b]pyridine 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC2=C(C(=CN2)Br)N=C1

Technology Process of 3-bromo-6-methyl-1H-pyrrolo[3,2-b]pyridine

There total 1 articles about 3-bromo-6-methyl-1H-pyrrolo[3,2-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1175015-76-5
6-methyl-1H-pyrrolo[3,2-b]pyridine

: 1190323-01-3
3-bromo-6-methyl-1H-pyrrolo[3,2-b]pyridine

Guidance literature:: With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 0 ℃; for 1h; Inert atmosphere; Schlenk technique;
DOI:10.1016/j.bmcl.2014.06.028

Reference yield:

: 1190323-01-3
3-bromo-6-methyl-1H-pyrrolo[3,2-b]pyridine

: 1620098-34-1
4-(1,6-dimethyl-1H-pyrrolo[3,2-b]pyridin-3-yl)phenol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere; Schlenk technique

1.2: 1 h / 20 °C / Inert atmosphere; Schlenk technique

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 80 °C / Inert atmosphere; Schlenk technique

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; potassium carbonate; In water; N,N-dimethyl-formamide; mineral oil; 2.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.06.028

Reference yield:

: 1190323-01-3
3-bromo-6-methyl-1H-pyrrolo[3,2-b]pyridine

: 1620098-41-0
3-(4-([3,4'-bipyridin]-2-yloxy)phenyl)-1,6-dimethyl-1H-pyrrolo[3,2-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere; Schlenk technique

1.2: 1 h / 20 °C / Inert atmosphere; Schlenk technique

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 80 °C / Inert atmosphere; Schlenk technique

3.1: caesium carbonate / dimethyl sulfoxide / 12 h / 80 °C / Inert atmosphere; Schlenk technique

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; potassium carbonate; caesium carbonate; In water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil; 2.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.06.028