5-Bromo-4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine

Base Information

• Chemical Name: 5-Bromo-4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine
• CAS No.: 870706-48-2
• Molecular Formula: C9H9BrClN3
• Molecular Weight: 274.548
• Hs Code.: 2933990090
• Mol file: 870706-48-2.mol

Synonyms:5-Bromo-4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine

Chemical Property of 5-Bromo-4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine

Chemical Property:

• PSA: 30.71000
• LogP: 3.42810
• Storage Temp.: 2-8°C

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

5-Bromo-4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine 95+% ^*data from reagent suppliers

Safty Information:

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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine

There total 2 articles about 5-Bromo-4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine (870706-47-1) → 5-bromo-4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine (870706-48-2)

Guidance literature:

With N-Bromosuccinimide; In dichloromethane; for 12h;

Reference yield:

4-chloro-1H-pyrrolo[2,3-d]pyrimidine (3680-69-1) → 5-bromo-4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine (870706-48-2)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

2: N-Bromosuccinimide / dichloromethane / 12 h / 20 °C

With N-Bromosuccinimide; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2013.03.012

Reference yield: 73.0%

3-nitro-N-methoxy-N-methylbenzamide + 5-bromo-4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine (870706-48-2) → C16H13ClN4O3

Guidance literature:

5-bromo-4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 1h;

3-nitro-N-methoxy-N-methylbenzamide; In diethyl ether; hexane; for 1h;

DOI:10.1016/j.bmcl.2013.03.012

upstream raw materials:

4-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

Downstream raw materials:

1-[3-(4-amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-phenyl]-3-(4-chloro-phenyl)-urea

C₁₆H₁₇N₅O

C₁₆H₁₅N₅O₃

1-[3-(4-amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-phenyl]-3-(2-fluoro-5-methyl-phenyl)-urea

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