Ralimetinib

Base Information

Chemical Name:Ralimetinib
CAS No.:1029939-86-3
Molecular Formula:
Molecular Weight:0
Hs Code.:
Mol file:1029939-86-3.mol

Synonyms:Ralimetinib

Suppliers and Price of Ralimetinib

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Ralimetinib

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Ralimetinib

There total 11 articles about Ralimetinib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 2-(4-(dispiro[adamantane-2,3'-[1,2,4]trioxolane-5',1''-cyclohexan]-4''-yl)phenoxy)-1-morpholinoethan-1-one

: 1029939-86-3
4-(2-(4-(dispiro[adamantane-2,3'-[1,2,4]trioxolane-5',1''-cyclohexan]-4''-yl)phenoxy)ethyl)morpholine

Guidance literature:: With Triethoxysilane; zinc diacetate; In tetrahydrofuran; dichloromethane; at 60 ℃; for 20h; Inert atmosphere; Schlenk technique;
DOI:10.1021/acs.orglett.5b01307

Reference yield:

: 76300-15-7
adamantan-2-one O-methyloxime

: 1029939-86-3
4-(2-(4-(dispiro[adamantane-2,3'-[1,2,4]trioxolane-5',1''-cyclohexan]-4''-yl)phenoxy)ethyl)morpholine

Guidance literature:: Multi-step reaction with 3 steps

1.1: ozone / ethyl acetate / 937.59 Torr / Flow reactor

2.1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / acetonitrile / 0.5 h / 25 °C

2.2: 12 h / 60 °C

3.1: dimethylsulfide borane complex / 15 h / 20 °C

With dimethylsulfide borane complex; tetra(n-butyl)ammonium hydrogensulfate; ozone; sodium hydroxide; In ethyl acetate; acetonitrile; 1.1: |Griesbaum Coozonolysis;
DOI:10.1021/acs.orglett.5b01307

Reference yield:

: 92-88-6
4,4'-Dihydroxybiphenyl

: 1029939-86-3
4-(2-(4-(dispiro[adamantane-2,3'-[1,2,4]trioxolane-5',1''-cyclohexan]-4''-yl)phenoxy)ethyl)morpholine

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen; palladium on carbon / ethanol; water / 100 °C / 3750.38 Torr / Flow reactor

2.1: dmap; triethylamine / dichloromethane / 20 °C / Flow reactor

3.1: ozone / ethyl acetate / 937.59 Torr / Flow reactor

4.1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / acetonitrile / 0.5 h / 25 °C

4.2: 12 h / 60 °C

5.1: zinc diacetate; Triethoxysilane / tetrahydrofuran; dichloromethane / 20 h / 60 °C / Inert atmosphere; Schlenk technique

With dmap; Triethoxysilane; palladium on carbon; zinc diacetate; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; ozone; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; acetonitrile; 3.1: |Griesbaum Coozonolysis;
DOI:10.1021/acs.orglett.5b01307