N-[(1R,2R)-2-aMinocyclohexyl]-N'-[[(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-diMethyl-7-(1-Methylethyl)-1-phenanthrenyl]Methyl]-Thiourea

Base Information

Chemical Name:N-[(1R,2R)-2-aMinocyclohexyl]-N'-[[(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-diMethyl-7-(1-Methylethyl)-1-phenanthrenyl]Methyl]-Thiourea
CAS No.:1094496-54-4
Molecular Formula:C27H43N3S
Molecular Weight:441.71542
Hs Code.:
Mol file:1094496-54-4.mol

Synonyms:N-[(1R,2R)-2-aMinocyclohexyl]-N'-[[(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-diMethyl-7-(1-Methylethyl)-1-phenanthrenyl]Methyl]-Thiourea;N-[(1R,2R)-2-Aminocyclohexyl]-N'-[[(1R,4aS,10aR)- 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-isopropyl - 1-phenanthrenyl]methyl]thiourea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(1R,2R)-2-aMinocyclohexyl]-N'-[[(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-diMethyl-7-(1-Methylethyl)-1-phenanthrenyl]Methyl]-Thiourea

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of N-[(1R,2R)-2-aMinocyclohexyl]-N'-[[(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-diMethyl-7-(1-Methylethyl)-1-phenanthrenyl]Methyl]-Thiourea

There total 1 articles about N-[(1R,2R)-2-aMinocyclohexyl]-N'-[[(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-diMethyl-7-(1-Methylethyl)-1-phenanthrenyl]Methyl]-Thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 115269-93-7
(1R,4aS)-7-isopropyl-1-(isothiocyanatomethyl)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene

: 20439-47-8
(1R,2R)-1,2-diaminocyclohexane

: 1094496-54-4
1-((1R,2R)-2-aminocyclohexyl)-3-(((1R,4aS,10ar)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)methyl)thiourea

Guidance literature:: In dichloromethane; at 20 ℃; for 13.5h; Inert atmosphere;
DOI:10.1021/ol8025268

Reference yield: 80.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1094496-54-4
1-((1R,2R)-2-aminocyclohexyl)-3-(((1R,4aS,10ar)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)methyl)thiourea

: 1173373-71-1
1-((1R,2R)-2-(dimethylamino)cyclohexyl)-3-(((1R,4aS,10aR)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)methyl)thiourea

Guidance literature:: formaldehyd; 1-((1R,2R)-2-aminocyclohexyl)-3-(((1R,4aS,10ar)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)methyl)thiourea; In water; acetonitrile; at 20 ℃; for 0.25h;

With sodium cyanoborohydride; In water; acetonitrile; at 20 ℃; for 0.25h;

With acetic acid; In water; acetonitrile; at 20 ℃; for 2h;
DOI:10.1021/acs.orglett.8b03540