TEMAFLOXACIN HYDROCHLORIDE

Base Information

• Chemical Name: TEMAFLOXACIN HYDROCHLORIDE
• CAS No.: 105784-61-0
• Molecular Formula: C21H18 F3 N3 O3 . Cl H
• Molecular Weight: 453.848
• Mol file: 105784-61-0.mol

Synonyms:3-Quinolinecarboxylicacid,1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-,monohydrochloride (9CI); Abbott 62254; Omniflox; Temafloxacin hydrochloride

Chemical Property of TEMAFLOXACIN HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 1.11E-15mmHg at 25°C
• Boiling Point: 608.9°C at 760 mmHg
• Flash Point: 322.1°C
• PSA: 74.57000
• LogP: 4.10010
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: ≤2mg/ml in DMSO;5mg/ml in dimethyl formamide

Purity/Quality:

99% ^*data from raw suppliers

TemafloxacinHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Temafloxacin hydrochloride is a new fluoroquinolone antibacterial structurally and mechanistically related to tosufloxacin, another microbial DNA topoisomerase inhibitor introduced in 1990. It is particularly useful against beta-lactamase producing organisms and is indicated for the treatment of respiratory and urinary tract infections as well as sexually transmitted diseases, skin and soft tissue infections. The compound has high tissue penetration and is reported to have a low propensity to cause adverse effects and drug interactions.
• Uses: Temafloxacin Hydrochloride is an antimicrobial quinolone drug. Antibacterial (microbial DNA topoisomerase inhibitor).

Technology Process of TEMAFLOXACIN HYDROCHLORIDE

There total 11 articles about TEMAFLOXACIN HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl 7-(3-methyl-4-tert-butoxycarbonylpiperazin-1-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxoquinoline-3-carboxylate (144647-69-8) → Temafloxacin hydrochloride (105784-61-0)

Guidance literature:

With hydrogenchloride; acetic acid; at 100 ℃; for 2.5h;

DOI:10.1139/v92-170

Reference yield: 94.7%

C25H23BF3N3O7 → Temafloxacin hydrochloride (105784-61-0)

Guidance literature:

With hydrogenchloride; In water; at 0 ℃; for 4h; pH=< 1;

Reference yield:

quinoline (91-22-5) + 1-(2,4-Difluorophenyl)-1,4-dihydro-4-oxo-6-fluoro-7-(3-methyl-4-tert-butyloxycarbonyl-piperazin-1-yl)-3-quinoline carboxylic acid → Temafloxacin hydrochloride (105784-61-0)

Guidance literature:

In hydrogenchloride; acetonitrile; trifluoroacetic acid;

upstream raw materials:

ethyl 7-(3-methyl-4-tert-butoxycarbonylpiperazin-1-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxoquinoline-3-carboxylate

(RS)-2-methylpiperazine

2',4',5'-trifluoroacetophenone

2,5-difluoro-4-(3-methyl-4-tert-butoxycarbonylpiperazin-1-yl)acetophenone

Refernces

• 1、 Chu,Lico,Clairborne,Faubl. "An alternative synthesis of temafloxacin, a potent antibacterial agent". . p. 1323 - 1327. Retrieved 2007/10/02.