α-Methylhistamine dihydrochloride

Base Information

• Chemical Name: α-Methylhistamine dihydrochloride
• CAS No.: 36376-49-5
• Molecular Formula: C₆H₁₁N₃*2ClH
• Molecular Weight: 198.095
• Mol file: 36376-49-5.mol

Synonyms:2-(1H-Imidazol-4-yl)-1-methyl-ethylamine dihydrochloride

Chemical Property of α-Methylhistamine dihydrochloride

Chemical Property:

• Vapor Pressure: 7.26E-06mmHg at 25°C
• Boiling Point: 371.1°C at 760 mmHg
• Flash Point: 178.2°C
• PSA: 54.70000
• LogP: 2.60370

Purity/Quality:

97% ^*data from raw suppliers

2-(1H-Imidazol-4-yl)-1-methyl-ethylaminedihydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of α-Methylhistamine dihydrochloride

There total 1 articles about α-Methylhistamine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(S)-(+)-4-(2-amino-3-chloropropyl)-imidazole dihydrochloride (75614-85-6,75614-86-7) → (R)(?)-α-methyl-1H-imidazole-4-ethanamine dihydrochloride (36376-49-5,75614-89-0,75614-90-3,148025-93-8)

Guidance literature:

With hydrogenchloride; hydrogen; sodium acetate; acetic acid; palladium on activated charcoal; 1.) water, 25 deg C, 500 psi, 144 h;

DOI:10.1016/S0040-4020(01)86299-2

Reference yield:

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) + (R)(?)-α-methyl-1H-imidazole-4-ethanamine dihydrochloride (36376-49-5,75614-89-0,75614-90-3,148025-93-8) → (R)-3,3,3-Trifluoro-2-methoxy-N-{(R)-1-methyl-2-[1-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyl)-1H-imidazol-4-yl]-ethyl}-2-phenyl-propionamide (148042-67-5)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 25 ℃; for 17h;

DOI:10.1016/S0040-4020(01)86299-2

Reference yield:

(R)(?)-α-methyl-1H-imidazole-4-ethanamine dihydrochloride (36376-49-5,75614-89-0,75614-90-3,148025-93-8) → N-<2-(1H-imidazol-4-yl)-1(R)-methylethyl>-(R)-α-methoxy-α-(trifluoromethyl)benzeneacetamide

Guidance literature:

Multi-step reaction with 2 steps

1: NEt₃ / dimethylformamide / 17 h / 25 °C

2: K₂CO₃ / methanol; H₂O / 2 h / 25 °C

With potassium carbonate; triethylamine; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)86299-2

upstream raw materials:

(S)-(+)-4-(2-amino-3-chloropropyl)-imidazole dihydrochloride

Downstream raw materials:

(R)-3,3,3-Trifluoro-2-methoxy-N-{(R)-1-methyl-2-[1-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyl)-1H-imidazol-4-yl]-ethyl}-2-phenyl-propionamide

R-(+)-α,N^α-Dimethylhistamin

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