TERT-BUTYL 2-(BENZO[D]THIAZOL-2-YL)ACETATE

Base Information

• Chemical Name: TERT-BUTYL 2-(BENZO[D]THIAZOL-2-YL)ACETATE
• CAS No.: 886193-82-4
• Molecular Formula: C₁₃H₁₅NO₂S
• Molecular Weight: 249.334
• Mol file: 886193-82-4.mol

Synonyms:TERT-BUTYL 2-(BENZO[D]THIAZOL-2-YL)ACETATE

Chemical Property of TERT-BUTYL 2-(BENZO[D]THIAZOL-2-YL)ACETATE

Chemical Property:

• PSA: 67.43000
• LogP: 3.18050

Purity/Quality:

98%min ^*data from raw suppliers

TERT-BUTYL-2-(BENZO[D]THIAZOL-2-YL)ACETATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 2-(BENZO[D]THIAZOL-2-YL)ACETATE

There total 1 articles about TERT-BUTYL 2-(BENZO[D]THIAZOL-2-YL)ACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-chlorobenzo[d][1,3]thiazole (615-20-3) + acetic acid tert-butyl ester (540-88-5) → tert-butyl 2-(benzo[d]thiazol-2-yl)acetate (886193-82-4)

Guidance literature:

2-chlorobenzo[d][1,3]thiazole; acetic acid tert-butyl ester; With chloro(2-di-tertbutylphosphino-2',4',6'-tri-2-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II); lithium hexamethyldisilazane; In toluene; at 20 ℃; for 4h; Inert atmosphere;

With ammonium chloride; In water; toluene; Inert atmosphere;

DOI:10.1021/ol900295u

Reference yield:

tert-butyl 2-(benzo[d]thiazol-2-yl)acetate (886193-82-4) + 4-methyl-β-nitrostyrene (7559-36-6,5153-68-4) → 2-[(2R)-2-(4-methylphenyl)-3-nitropropyl]-1,3-benzothiazole (1403684-00-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: C₄₀H₄₈Br₂N₄Ni / 1,4-dioxane / 0.08 h / 20 °C / Molecular sieve

1.2: 18 h / 20 °C / Molecular sieve

2.1: toluene-4-sulfonic acid / toluene / 3 h / Reflux

With C₄₀H₄₈Br₂N₄Ni; toluene-4-sulfonic acid; In 1,4-dioxane; toluene; 1.2: |Michael Addition;

DOI:10.1002/chem.201202093

upstream raw materials:

2-chlorobenzo[d][1,3]thiazole

acetic acid tert-butyl ester

Downstream raw materials:

2-[(2R)-2-(4-methylphenyl)-3-nitropropyl]-1,3-benzothiazole

Refernces

• 1、 Shen, Hong C.,Ding, Fa-Xiang,Colletti, Steven L.. "α-Heteroarylation of esters, lactones, amides, and lactams by nucleophilic aromatic substitution". . p. 1447 - 1450. Retrieved 2007/10/03.