Chemical Property of 6,7-Dihydro-3-[(2-hydroxyethyl)thio]-6,6-dimethyl-1-(2-thiazolyl)-benzo[C]thiophen-4(5H)-one
Chemical Property:
- PSA：131.97000
- LogP:4.11110
- Storage Temp.:Store at +4°C
- XLogP3:3.4
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:4
- Exact Mass:339.04214231
- Heavy Atom Count:21
- Complexity:404
- Purity/Quality:
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>98% *data from raw suppliers
TB 21007 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1(CC2=C(SC(=C2C(=O)C1)SCCO)C3=NC=CS3)C
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Description
TB 21007 is an inverse agonist of α5β3γ2 subunit-containing GABAA receptors (Ki = 1.6 nM). It selectively inhibits α5β3γ2 subunit-containing GABAA receptors over α1-4 and α6 subunit-containing GABAA receptors that also contain β3 and γ2 subunits (Kis = 20, 16, 20, 106, and 1,800 nM, respectively). TB 21007 reduces the latency to find the hidden platform in a matching-to-place variant of the Morris water maze, indicating enhanced spatial memory, in rats when administered at a dose of 0.3 mg/kg. It reduces paw tactile allodynia induced by reserpine in a rat model of fibromyalgia-like pain when administered intrathecally at doses of 1.5, 15, and 150 nmol.
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Uses
TB 21007 is a selective GABAA α5 receptor inverse agonist which enhances cognition.
