(1S,2R)-2-Amino-cyclooctanecarboxylic acid hydrochloride

Base Information

• Chemical Name: (1S,2R)-2-Amino-cyclooctanecarboxylic acid hydrochloride
• CAS No.: 522644-10-6
• Molecular Formula: C₉H₁₇NO₂*ClH
• Molecular Weight: 207.7
• Hs Code.: 2922498590
• European Community (EC) Number: 895-896-0
• Mol file: 522644-10-6.mol

Synonyms:522644-10-6;350015-76-8;(1S,2R)-2-Amino-cyclooctanecarboxylic acid hydrochloride;(+/-)-cis-2-Aminocyclo-octane-1-carboxylic acid hydrochloride;(1S,2R)-2-aminocyclooctane-1-carboxylic acid hydrochloride;(1S,2R)-2-aminocyclooctane-1-carboxylic acid;hydrochloride;cis-2-Amino-1-cyclooctanecarboxylic acid hydrochloride;MFCD08669706;AKOS030241952;TS-7066;DB-299475;CIS-2-AMINO-1-CYCLOOCTANECARBOXYLIC ACI&;EN300-6489826;(1S,2R)-2-Aminocyclooctanecarboxylic acid hydrochloride;(1S,2R)-2-Amino-cyclooctane carboxylic acid hydrochloride;rac-(1R,2S)-2-aminocyclooctane-1-carboxylic acid hydrochloride

Chemical Property of (1S,2R)-2-Amino-cyclooctanecarboxylic acid hydrochloride

Chemical Property:

• PSA: 63.32000
• LogP: 2.87100
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 207.1026065
• Heavy Atom Count: 13
• Complexity: 159

Purity/Quality:

98%min ^*data from raw suppliers

(1S,2R)-2-AMINO-CYCLOOCTANECARBOXYLIC ACID HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCCC(C(CC1)C(=O)O)N.Cl
• Isomeric SMILES: C1CCC[C@H]([C@H](CC1)C(=O)O)N.Cl

Technology Process of (1S,2R)-2-Amino-cyclooctanecarboxylic acid hydrochloride

There total 21 articles about (1S,2R)-2-Amino-cyclooctanecarboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(1R,2S)-2-Amino-cyclooctanecarboxylic acid (522644-04-8,791059-05-7) → (1S,2R)-2-Amino-cyclooctanecarboxylic acid; hydrochloride (522644-10-6,522644-08-2)

Guidance literature:

With hydrogenchloride; In water; for 3h; Heating;

DOI:10.1021/ol034096o

Reference yield: 75.0%

C9H15NO2 → (1S,2R)-2-Amino-cyclooctanecarboxylic acid; hydrochloride (522644-10-6,522644-08-2)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 6h;

DOI:10.3390/molecules22122211

Reference yield: 74.0%

ethyl trans-2-aminocyclooctanecarboxylate (772330-11-7,758676-44-7) → trans-2-aminocyclooctanecarboxylic acid hydrochloride (522644-10-6,522644-08-2)

Guidance literature:

With hydrogenchloride; at 20 ℃; for 30h;

DOI:10.1055/s-2005-861875

upstream raw materials:

(1R,2S)-2-Amino-cyclooctanecarboxylic acid

(1R,2R)-ethyl 2-aminocyclooctanecarboxylate

ethyl trans-2-aminocyclooctanecarboxylate

ethyl 2-oxocyclooctane-1-carboxylate

Refernces

• 1、 Forró, Eniko,Kiss, Loránd,árva, Judit,Fül?p, Ferenc. "Efficient enzymatic routes for the synthesis of new eight-membered cyclic β-amino acid and β-lactam enantiomers". . . Retrieved 2018/01/17.
• 2、 Forro, Eniko,Arva, Judit,Fueloep, Ferenc. "Preparation of (1R,8S)- and (1S,8R)-9-azabicyclo[6.2.0]dec-4-en-10-one: Potential starting compounds for the synthesis of anatoxin-a". . p. 643 - 649. Retrieved 2007/10/03.