(R)-N-BOC-(2'-CHLOROPHENYL)GLYCINE

Base Information

• Chemical Name: (R)-N-BOC-(2'-CHLOROPHENYL)GLYCINE
• CAS No.: 1212602-23-7
• Molecular Formula: C13H16ClNO4
• Molecular Weight: 285.727
• Mol file: 1212602-23-7.mol

Synonyms:(R)-TERT-BUTOXYCARBONYLAMINO-(2-CHLORO-PHENYL)-ACETIC ACID;(R)-N-BOC-(2'-CHLOROPHENYL)GLYCINE;(R)-2-(TERTBUTOXYCARBONYLAMINO)-2-(2-CHLOROPHENYL)ACETIC ACID

Chemical Property of (R)-N-BOC-(2'-CHLOROPHENYL)GLYCINE

Chemical Property:

• Boiling Point: 431.5±40.0 °C(Predicted)
• PKA: 3.26±0.10(Predicted)
• PSA: 75.63000
• Density: 1.272±0.06 g/cm3(Predicted)
• LogP: 3.38130
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(R)-N-Boc-(2''-chlorophenyl)glycine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-BOC-(2'-CHLOROPHENYL)GLYCINE

There total 1 articles about (R)-N-BOC-(2'-CHLOROPHENYL)GLYCINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-((tert-butoxycarbonyl)amino)-2-(2-chlorophenyl)acetate (1253091-76-7) → (R)-(-)-methyl 2-(tert-butoxycarbonylamino)-2-(2-chlorophenyl)acetate (1001414-68-1) + (2R)-[(tert-butoxycarbonyl)amino](2-chlorophenyl)ethanoic acid (1212602-23-7,225918-60-5) + N-Boc-(S)-2-chlorophenylglycine (225918-60-5)

Guidance literature:

With Alcalase-CLEA; In acetonitrile; at 20 ℃; for 15h; pH=8; optical yield given as %ee; aq. buffer; Resolution of racemate;

DOI:10.1016/j.tetasy.2010.06.040

Reference yield: 82.72%

(2R)-[(tert-butoxycarbonyl)amino](2-chlorophenyl)ethanoic acid (1212602-23-7,225918-60-5) + 6-{2H,4H,5H,6H-pyrrolo[3,4-c]pyrazole-2-sulfonyl}-1,3-benzothiazole → tert-butyl N-[(1R)-2-[2-(1,3-benzothiazole-6-sulfonyl)-2H,4H,5H,6H-pyrrolo[3,4-c]pyrazol-5-yl]-1-(2-chlorophenyl)-2-oxoethyl]carbamate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

(2R)-[(tert-butoxycarbonyl)amino](2-chlorophenyl)ethanoic acid (1212602-23-7,225918-60-5) + tert-butyl 4-(4-amino-2-methoxyphenyl)-1H-pyrazole-1-carboxylate (1610875-72-3) → C28H33ClN4O6

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 ℃;

DOI:10.1016/j.bmcl.2020.127495

upstream raw materials:

methyl 2-((tert-butoxycarbonyl)amino)-2-(2-chlorophenyl)acetate

Downstream raw materials:

(R)-ethyl 2-((2-(2-amino-2-(2-chlorophenyl)acetyl)oxyethylcarbamoyloxy)methyl)-5,7-dimethyl-3-(2-(N-methylsulfamoyl)phenyl)-4-oxo-3,4-dihydroquinazoline-6-carboxylate