1,12-Epoxy-9H-indolo[3,2,1-de]phenanthridine,9a,10,11,12,13,13a-hexahydro-2,9,9,12-tetramethyl-, (9aR,12S,13aS)-rel-(+)-

Base Information

Chemical Name:1,12-Epoxy-9H-indolo[3,2,1-de]phenanthridine,9a,10,11,12,13,13a-hexahydro-2,9,9,12-tetramethyl-, (9aR,12S,13aS)-rel-(+)-
CAS No.:25488-37-3
Molecular Formula:C₂₃H₂₅NO
Molecular Weight:331.458
Hs Code.:
Mol file:25488-37-3.mol

Synonyms:1,12-Epoxy-9H-indolo[3,2,1-de]phenanthridine,9a,10,11,12,13,13a-hexahydro-2,9,9,12-tetramethyl-, (9aa,12b,13aa)-; (+)-Murrayazoline; Curryangin; Curryangine; Mahanimbidin;Mahanimbidine; Murrayazoline

Suppliers and Price of 1,12-Epoxy-9H-indolo[3,2,1-de]phenanthridine,9a,10,11,12,13,13a-hexahydro-2,9,9,12-tetramethyl-, (9aR,12S,13aS)-rel-(+)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Murrayazoline
1mg
$ 165.00

Total 0 raw suppliers

Chemical Property of 1,12-Epoxy-9H-indolo[3,2,1-de]phenanthridine,9a,10,11,12,13,13a-hexahydro-2,9,9,12-tetramethyl-, (9aR,12S,13aS)-rel-(+)-

Chemical Property:

PSA：14.16000
LogP:5.88640

Purity/Quality:: Murrayazoline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Murrayazoline is a pyranocarbazole alkaloid isolated from Murraya koenigii leaves with anti-colon cancer activity. It induces mTOR/AKT downregulation and mitochondrial apoptosis.

Technology Process of 1,12-Epoxy-9H-indolo[3,2,1-de]phenanthridine,9a,10,11,12,13,13a-hexahydro-2,9,9,12-tetramethyl-, (9aR,12S,13aS)-rel-(+)-

There total 16 articles about 1,12-Epoxy-9H-indolo[3,2,1-de]phenanthridine,9a,10,11,12,13,13a-hexahydro-2,9,9,12-tetramethyl-, (9aR,12S,13aS)-rel-(+)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 21104-28-9,24948-14-9
mahanimbine

: 25488-37-3
mahanimbidine

: cyclomahanimbine

Guidance literature:: With camphor-10-sulfonic acid; In hexane; for 45h; Overall yield = 96 %; Overall yield = 47.8 mg; Inert atmosphere; Darkness;
DOI:10.1002/chem.201301792

Reference yield:

: 219492-11-2
2-(benzyloxy)-1-methyl-4-nitrobenzene

: 25488-37-3
mahanimbidine

: cyclomahanimbine

Guidance literature:: Multi-step reaction with 6 steps

1: iron; acetic acid / 4 h / 45 °C / Inert atmosphere

2: caesium carbonate; palladium diacetate; XPhos / toluene / 16 h / Inert atmosphere; Reflux

3: potassium carbonate; palladium diacetate; trimethylpyruvic acid / 23 h / 85 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / methanol; dichloromethane / 72 h / 20 °C / Inert atmosphere

5: titanium(IV)isopropoxide / toluene / 15 h / -78 - 20 °C / Inert atmosphere

6: camphor-10-sulfonic acid / hexane / 45 h / Inert atmosphere; Darkness

With palladium 10% on activated carbon; camphor-10-sulfonic acid; hydrogen; palladium diacetate; titanium(IV)isopropoxide; iron; potassium carbonate; caesium carbonate; acetic acid; trimethylpyruvic acid; XPhos; In methanol; hexane; dichloromethane; toluene; 2: |Buchwald-Hartwig Coupling;
DOI:10.1002/chem.201301792

Reference yield:

: 219492-12-3
3-(benzyloxy)-4-methylaniline

: 25488-37-3
mahanimbidine

: cyclomahanimbine

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate; palladium diacetate; XPhos / toluene / 16 h / Inert atmosphere; Reflux

2: potassium carbonate; palladium diacetate; trimethylpyruvic acid / 23 h / 85 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol; dichloromethane / 72 h / 20 °C / Inert atmosphere

4: titanium(IV)isopropoxide / toluene / 15 h / -78 - 20 °C / Inert atmosphere

5: camphor-10-sulfonic acid / hexane / 45 h / Inert atmosphere; Darkness

With palladium 10% on activated carbon; camphor-10-sulfonic acid; hydrogen; palladium diacetate; titanium(IV)isopropoxide; potassium carbonate; caesium carbonate; trimethylpyruvic acid; XPhos; In methanol; hexane; dichloromethane; toluene; 1: |Buchwald-Hartwig Coupling;
DOI:10.1002/chem.201301792