4-(Boc-aMinoMethyl)-6-chloropyriMidine

Base Information

• Chemical Name: 4-(Boc-aMinoMethyl)-6-chloropyriMidine
• CAS No.: 1389264-32-7
• Molecular Formula: C10H14ClN3O2
• Molecular Weight: 243.69006
• Mol file: 1389264-32-7.mol

Synonyms:4-(Boc-aMinoMethyl)-6-chloropyriMidine;tert-butyl N-[(6-chloropyrimidin-4-yl)methyl]carbamate;tert-Butyl ((6-chloropyrimidin-4-yl)methyl)carbamate

Chemical Property of 4-(Boc-aMinoMethyl)-6-chloropyriMidine

Chemical Property:

• PSA: 64.11000
• LogP: 2.54560
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-ButylN-[(6-Chloropyrimidin-4-Yl)Methyl]Carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(Boc-aMinoMethyl)-6-chloropyriMidine

There total 2 articles about 4-(Boc-aMinoMethyl)-6-chloropyriMidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.5%

C14H18ClN3O5 → tert-butyl N-[(6-chloropyrimidin-4-yl)methyl]carbamate (1389264-32-7)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

(6-chloropyrimidin-4-yl)methanol (1025351-41-0) + ethyl 2-{[(tert-butoxy)carbonyl]amino}-2-oxoacetate (216959-34-1) → tert-butyl N-[(6-chloropyrimidin-4-yl)methyl]carbamate (1389264-32-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 4 h / 0 - 20 °C

2: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

With water; triphenylphosphine; lithium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; 1: |Mitsunobu Displacement;

upstream raw materials:

(6-chloropyrimidin-4-yl)methanol

ethyl 2-{[(tert-butoxy)carbonyl]amino}-2-oxoacetate

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