2-(3,4-DICHLOROPHENYL)PENT-4-ENOIC ACID N-METHYLAMIDE

Base Information

• Chemical Name: 2-(3,4-DICHLOROPHENYL)PENT-4-ENOIC ACID N-METHYLAMIDE
• CAS No.: 206997-68-4
• Molecular Formula: C₁₂H₁₅Cl₂N
• Molecular Weight: 244.164
• Hs Code.: 2924299090
• Mol file: 206997-68-4.mol

Synonyms:2-(3,4-DICHLOROPHENYL)PENT-4-ENOIC ACID N-METHYLAMIDE;2-(3,4-Dichlorophenyl)-N-Methylpent-4-enaMide

Chemical Property of 2-(3,4-DICHLOROPHENYL)PENT-4-ENOIC ACID N-METHYLAMIDE

Chemical Property:

• Vapor Pressure: 0.000488mmHg at 25°C
• Boiling Point: 313.7°C at 760 mmHg
• Flash Point: 143.5°C
• PSA: 29.10000
• Density: 1.126g/cm³
• LogP: 3.79000

Purity/Quality:

99% ^*data from raw suppliers

2-(3,4-DICHLOROPHENYL)PENT-4-ENOIC ACID N-METHYLAMIDE 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3,4-DICHLOROPHENYL)PENT-4-ENOIC ACID N-METHYLAMIDE

There total 10 articles about 2-(3,4-DICHLOROPHENYL)PENT-4-ENOIC ACID N-METHYLAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-(3,4-dichlorophenyl)pent-4-enoic acid N-methyl amide (147643-61-6,885266-55-7) → (S)-N-methyl-(2-(3,4-dichlorophenyl)pent-4-enyl)amine (156300-01-5,206997-68-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/S0960-894X(00)00637-5

Reference yield:

(S)-2-(3,4-dichlorophenyl)pent-4-enoic acid, N-methyl amide (885266-55-7) → (S)-N-methyl-(2-(3,4-dichlorophenyl)pent-4-enyl)amine (156300-01-5,206997-68-4)

Guidance literature:

With sulfuric acid; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

(2S)-2-(3,4-dichlorophenyl)pent-4-enoic acid (147643-57-0) → (S)-N-methyl-(2-(3,4-dichlorophenyl)pent-4-enyl)amine (156300-01-5,206997-68-4)

Guidance literature:

Multi-step reaction with 3 steps

1: (COCl)2; DMF / CH₂Cl₂ / 20 °C

2: tetrahydrofuran / 20 °C

3: LAH / tetrahydrofuran / 20 °C

With lithium aluminium tetrahydride; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0960-894X(00)00637-5

upstream raw materials:

(S)-2-(3,4-dichlorophenyl)pent-4-enoic acid N-methyl amide

3,4-dichlorophenyl acetic acid

2-(S)-(3,4-dichloro-phenyl)-4-pentenoic acid

(S)-2-(3,4-dichlorophenyl)pent-4-enoyl chloride

Refernces

• 1、 Huang, Shih-Chung,Undem, Bradley,Korlipara, Vijaya. "Design and synthesis of substituted N-methylbenzamide analogues derived from SR 48,968 as neurokinin-2 receptor antagonists". . p. 4779 - 4782. Retrieved 2007/10/03.
• 2、 Finke, Paul E.,Meurer, Laura C.,Oates, Bryan,Mills, Sander G.,MacCoss, Malcolm,Malkowitz, Lorraine,Springer, Martin S.,Daugherty, Bruce L.,Gould, Sandra L.,DeMartino, Julie A.,Siciliano, Salvatore J.,Carella, Anthony,Carver, Gwen,Holmes, Karen,Danzeisen, Renee,Hazuda, Daria,Kessler, Joseph,Lineberger, Janet,Miller, Michael,Schleif, William A.,Emini, Emilio A.. "Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 2: Structure-activity relationships for substituted 2-aryl-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-(piperidin-1-yl)butanes". . p. 265 - 270. Retrieved 2007/10/03.