(1R)-1,4,4aβ,5,6,7,8,8a-Octahydro-2,5,5,8aα-tetramethylnaphthalene-1α-acetaldehyde

Base Information

Chemical Name:(1R)-1,4,4aβ,5,6,7,8,8a-Octahydro-2,5,5,8aα-tetramethylnaphthalene-1α-acetaldehyde
CAS No.:88862-14-0
Molecular Formula:C₁₆H₂₆O
Molecular Weight:234.382
Hs Code.:
Mol file:88862-14-0.mol

Synonyms:(1R)-1,4,4aβ,5,6,7,8,8a-Octahydro-2,5,5,8aα-tetramethylnaphthalene-1α-acetaldehyde

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Chemical Property of (1R)-1,4,4aβ,5,6,7,8,8a-Octahydro-2,5,5,8aα-tetramethylnaphthalene-1α-acetaldehyde

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Technology Process of (1R)-1,4,4aβ,5,6,7,8,8a-Octahydro-2,5,5,8aα-tetramethylnaphthalene-1α-acetaldehyde

There total 21 articles about (1R)-1,4,4aβ,5,6,7,8,8a-Octahydro-2,5,5,8aα-tetramethylnaphthalene-1α-acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 31207-73-5
2-((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6, 7,8,8a-octahydronaphthalen-1-yl)ethan-1-ol

: 116163-52-1,88862-14-0
2-((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)acetaldehyde

Guidance literature:: With pyridine-SO₃ complex; triethylamine; In dimethyl sulfoxide; at 20 ℃; for 1h;
DOI:10.1021/jo010154c

Reference yield: 91.0%

: 195702-97-7
N-methoxy-N-methyl-2-((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)acetamide

: 116163-52-1,88862-14-0
2-((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)acetaldehyde

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;
DOI:10.1016/S0040-4039(02)01392-8

Reference yield:

: 564-20-5,1216-84-8,30450-17-0,58976-28-6,64090-92-2,67844-42-2,79768-41-5,79768-42-6,86688-27-9,86688-28-0,95406-08-9,98719-44-9,98719-46-1,131831-65-7,140851-80-5
(3aR)-(+)-sclareolide

: 116163-52-1,88862-14-0
2-((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)acetaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / Me₃Al / CH₂Cl₂ / 0 - 20 °C

2: 32 percent / Cl₂SO; pyridine / 0 °C

3: 91 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 0 - 20 °C

With pyridine; lithium aluminium tetrahydride; thionyl chloride; trimethylaluminum; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(02)01392-8