2-(2-Bromophenyl)thiazole

Base Information

• Chemical Name: 2-(2-Bromophenyl)thiazole
• CAS No.: 30216-46-7
• Molecular Formula: C₉H₆BrNS
• Molecular Weight: 240.123
• DSSTox Substance ID: DTXSID301312100
• Mol file: 30216-46-7.mol

Synonyms:2-(2-Bromophenyl)thiazole;30216-46-7;2-(2-bromophenyl)-1,3-thiazole;2-(2-Bromo-phenyl)-thiazole;2-(2-bromophenyl)-thiazole;SCHEMBL5327036;FOKTWTQELZBNRT-UHFFFAOYSA-N;DTXSID301312100;1-bromo-2-(thiazol-2-yl)benzene;MFCD19381944;AKOS017411918;AS-5898;AT22774;DA-07137;CS-0450721;EN300-79218

Chemical Property of 2-(2-Bromophenyl)thiazole

Chemical Property:

• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 238.94043
• Heavy Atom Count: 12
• Complexity: 154

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C2=NC=CS2)Br

Technology Process of 2-(2-Bromophenyl)thiazole

There total 3 articles about 2-(2-Bromophenyl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-bromobenzothioamide (30216-44-5) + Bromoacetaldehyde diethyl acetal (2032-35-1) → 2-(2-bromophenyl)thiazole (30216-46-7)

Guidance literature:

In ethanol; for 4h; Reflux;

DOI:10.3987/COM-18-S(T)47

Reference yield:

o-cyanobromobenzene (2042-37-7) → 2-(2-bromophenyl)thiazole (30216-46-7)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂S, Et₃N / pyridine

2: 12 h / Heating

With hydrogen sulfide; triethylamine; In pyridine;

DOI:10.1139/v70-595

Reference yield:

2-chloroethanal (107-20-0) + 2-bromobenzothioamide (30216-44-5) → 2-(2-bromophenyl)thiazole (30216-46-7)

Guidance literature:

for 12h; Heating;

DOI:10.1139/v70-595

upstream raw materials:

2-chloroethanal

2-bromobenzothioamide

o-cyanobromobenzene

Bromoacetaldehyde diethyl acetal