trans-3,4-difluoropyrrolidine hydrochloride

Base Information

• Chemical Name: trans-3,4-difluoropyrrolidine hydrochloride
• CAS No.: 869481-92-5
• Molecular Formula: C₄H₇F₂N*ClH
• Molecular Weight: 143.564
• Mol file: 869481-92-5.mol

Synonyms:trans-3,4-difluoropyrrolidine hydrochloride

Chemical Property of trans-3,4-difluoropyrrolidine hydrochloride

Chemical Property:

• PSA: 12.03000
• LogP: 1.39660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

trans-3,4-DifluoropyrrolidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of trans-3,4-difluoropyrrolidine hydrochloride

There total 5 articles about trans-3,4-difluoropyrrolidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(3R,4S)-3,4-Difluoro-pyrrolidine-1-carboxylic acid tert-butyl ester (932034-24-7) → (3R,4S)-3,4-difluoropyrrolidine hydrochloride (869481-92-5,869481-94-7,1279037-05-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

DOI:10.1016/j.bmcl.2005.07.026

Reference yield: 99.0%

(3S,4S)-1-Benzyl-3,4-difluoro-pyrrolidine → trans-(S,S)-3,4-difluoropyrrolidine hydrochloride (869481-92-5,869481-94-7,1279037-05-6)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1016/j.bmcl.2005.07.026

Reference yield: 96.0%

(3R,4R)-1-benzyl-3,4-difluoropyrrolidine hydrochloride → trans-(R,R)-3,4-difluoropyrrolidine hydrochloride (869481-92-5,869481-94-7,1279037-05-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; for 6h;

DOI:10.1021/acs.jmedchem.6b01163

upstream raw materials:

(3R,4S)-3,4-Difluoro-pyrrolidine-1-carboxylic acid tert-butyl ester

(3R,4S)-rel-3,4-difluoropyrrolidine-1-carboxylic acid benzyl ester

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