tert-butyl 5-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

Base Information

• Chemical Name: tert-butyl 5-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate
• CAS No.: 860436-56-2
• Molecular Formula: C₁₅H₂₁NO₃
• Molecular Weight: 263.337
• Mol file: 860436-56-2.mol

Synonyms:tert-butyl 5-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

Chemical Property of tert-butyl 5-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

Chemical Property:

• Boiling Point: 382.7±42.0 °C(Predicted)
• PKA: -1.50±0.20(Predicted)
• PSA: 38.77000
• Density: 1.104±0.06 g/cm3(Predicted)
• LogP: 2.92630

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl5-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 5-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

There total 2 articles about tert-butyl 5-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

di-tert-butyl dicarbonate (24424-99-5) + o-methoxy-2-phenylethylamine (2045-79-6) + paraformaldehyde → tert-butyl 5-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate (860436-56-2)

Guidance literature:

o-methoxy-2-phenylethylamine; paraformaldehyde; With magnesium sulfate; In dichloromethane; for 2h;

With trifluoroacetic acid; Heating / reflux;

di-tert-butyl dicarbonate; With triethylamine; In tetrahydrofuran; for 3h;

Reference yield:

5-methoxy-1,2,3,4-tetrahydro-isoquinoline (103030-70-2) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 5-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate (860436-56-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1016/j.bmc.2007.11.055

Reference yield: 100.0%

tert-butyl 5-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate (860436-56-2) → 1,2,3,4- tetrahydroisoquinolin-5-ol hydrobromide (860437-59-8)

Guidance literature:

With hydrogen bromide; at 105 ℃; for 5h;

DOI:10.1016/j.bmc.2007.11.055

upstream raw materials:

5-methoxy-1,2,3,4-tetrahydro-isoquinoline

di-tert-butyl dicarbonate

o-methoxy-2-phenylethylamine

Downstream raw materials:

1,2,3,4- tetrahydroisoquinolin-5-ol hydrobromide