Technology Process of 2-(allyloxyMethyl)aniline
There total 1 articles about 2-(allyloxyMethyl)aniline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride; acetic acid; tin(ll) chloride; zinc;
at 15 - 20 ℃;
for 1h;
- Guidance literature:
-
With
iron(III)-acetylacetonate; phenylsilane; sodium hydrogencarbonate; 4-Nitrobenzenesulfonyl chloride;
In
methanol;
at 0 - 20 ℃;
for 12h;
regioselective reaction;
Schlenk technique;
Inert atmosphere;
DOI:10.1002/anie.202015740
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: pyridine; Et3N / 3 h / -10 °C
1.2: DCC; pyridine / 15 h / -10 - 25 °C
2.1: CHCl3 / 4 h / Heating
3.1: HCl / H2O / 2 h / 80 - 90 °C
4.1: tBuOK / dimethylsulfoxide / 5 h / 60 °C
5.1: DBU / dimethylformamide / 7.5 h / 60 °C
6.1: aq. HCl / ethanol / 3 h / Heating
7.1: m-CPBA / CHCl3 / 0.58 h / 0 °C
8.1: Novozym 435, lipase from Candida antarctica / CH2Cl2 / 4 h / 20 °C
9.1: Et3N / CH2Cl2 / 2 h / 0 °C
10.1: LiBHEt3 / CH2Cl2; tetrahydrofuran / 1 h / 0 °C
With
pyridine; hydrogenchloride; Novozym 435; lipase from Candida antarctica; potassium tert-butylate; lithium triethylborohydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; ethanol; dichloromethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
1.1: Addition / 1.2: Elimination / 2.1: Addition / 3.1: Cyclization / 4.1: Isomerization / 5.1: Substitution / 6.1: Hydrolysis / 7.1: Oxidation / 8.1: Acetylation / 9.1: Esterification / 10.1: Reduction;
DOI:10.1016/S0040-4039(99)00946-6
