3-(4-FLUOROPHENOXY)PYRROLIDINE

Base Information

• Chemical Name: 3-(4-FLUOROPHENOXY)PYRROLIDINE
• CAS No.: 524045-02-1
• Molecular Formula: C10H12FNO
• Molecular Weight: 181.21
• Mol file: 524045-02-1.mol

Synonyms:3-(4-FLUOROPHENOXY)PYRROLIDINE;(S)-3-(4-Fluoro-phenoxy)-pyrrolidine

Chemical Property of 3-(4-FLUOROPHENOXY)PYRROLIDINE

Chemical Property:

• Boiling Point: 274.2±30.0 °C(Predicted)
• PKA: 10.56±0.10(Predicted)
• PSA: 21.26000
• Density: 1.143±0.06 g/cm3(Predicted)
• LogP: 1.89520

Purity/Quality:

97% ^*data from raw suppliers

3-(4-Fluorophenoxy)pyrrolidine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-FLUOROPHENOXY)PYRROLIDINE

There total 2 articles about 3-(4-FLUOROPHENOXY)PYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 3-(4-fluorophenoxy)pyrrolidine-1-carboxylate (950648-92-7,1314419-66-3) → 3-(4-fluorophenoxy)pyrrolidine (524045-02-1)

Guidance literature:

With hydrogenchloride; water; In 1,4-dioxane; ethanol; at 20 ℃; for 18h;

Reference yield:

→ 3-(4-fluorophenoxy)pyrrolidine (524045-02-1)

Guidance literature:

aus d. 1-Benzylverb.;

Reference yield:

Wang-iodide resin + 3-(4-fluorophenoxy)pyrrolidine (524045-02-1) → C16H23FN2O

Guidance literature:

Wang-iodide resin; 3-(4-fluorophenoxy)pyrrolidine; With N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 55 ℃; for 60h;

With trifluoroacetic acid; at 20 ℃; for 0.666667h;

With AMBERLYST^TM A-21;

upstream raw materials:

tert-butyl 3-(4-fluorophenoxy)pyrrolidine-1-carboxylate

Refernces

• 1、 -. "PYRIDINE AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS". Page/Page column 63. . Retrieved 2012/06/30.
• 2、 Welstead Jr.,Helsley,Duncan Jr.,Cale Jr.,Taylor,DaVanzo,Franko,Lunsford. "Aroylalkylpyrrolidines. Central nervous system depressants.". . p. 435 - 441. Retrieved 2007/10/05.