4-AMino-5-nitro-2-(trifluoroMethyl)benzonitrile

Base Information

• Chemical Name: 4-AMino-5-nitro-2-(trifluoroMethyl)benzonitrile
• CAS No.: 1155800-54-6
• Molecular Formula: C8H4F3N3O2
• Molecular Weight: 231.1314696
• Hs Code.: 2926907090
• Mol file: 1155800-54-6.mol

Synonyms:4-AMino-5-nitro-2-(trifluoroMethyl)benzonitrile;5-AMINO-2-CYANO-4-NITROBENZOTRIFLUORIDE

Chemical Property of 4-AMino-5-nitro-2-(trifluoroMethyl)benzonitrile

Chemical Property:

• PSA: 95.63000
• LogP: 3.17188

Purity/Quality:

97% ^*data from raw suppliers

4-Amino-5-nitro-2-(trifluoromethyl)benzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 4-Amino-5-nitro-2-(trifluoromethyl)benzonitrile, can be used in the synthesis of substituted benzene-1,2-diamines, which are functional building blocks for the preparation of biologically active heterocyclic molecules, such as, 2,5,6-trisubstitued benzimidazole derivatives as selective androgen receptor modulators (SARMs),

Technology Process of 4-AMino-5-nitro-2-(trifluoroMethyl)benzonitrile

There total 1 articles about 4-AMino-5-nitro-2-(trifluoroMethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.7%

N-(4-cyano-2-nitro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroacetamide (1155800-48-8) → 4-amino-5-nitro-2-(trifluoromethyl)benzonitrile (1155800-54-6)

Guidance literature:

With water; potassium carbonate; In methanol; at 20 ℃; for 4h; Large scale reaction;

DOI:10.1021/op9000498

Reference yield: 91.0%

4-amino-5-nitro-2-(trifluoromethyl)benzonitrile (1155800-54-6) → 5-cyano-6-trifluoromethyl-1,2-phenylenediamine (882978-62-3)

Guidance literature:

With hydrogenchloride; stannous chloride dihydrate; In tetrahydrofuran; water; at 0 - 20 ℃; Inert atmosphere; Large scale reaction;

DOI:10.1021/op9000498

upstream raw materials:

N-(4-cyano-2-nitro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroacetamide

Downstream raw materials:

5-cyano-6-trifluoromethyl-1,2-phenylenediamine